Effects of amisulpride, an atypical antipsychotic which blocks preferentially presynaptic dopamine autoreceptors, on integrated functional cerebral activity in the rat
| Autor: | Jesus Benavides, Dominique Fage, Bernard Scatton, Annie Cudennec |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Auditory Pathways medicine.drug_class Presynaptic Terminals Atypical antipsychotic Deoxyglucose Rats Sprague-Dawley Dopamine Internal medicine Dopamine receptor D2 medicine Haloperidol Animals Visual Pathways Amisulpride Molecular Biology Extrapyramidal Tracts Receptors Dopamine D2 General Neuroscience medicine.disease Corpus Striatum Rats Dopamine D2 Receptor Antagonists Endocrinology Glucose Schizophrenia Dopamine receptor Autoreceptor Dopamine Antagonists Neurology (clinical) Nerve Net Sulpiride Psychology Developmental Biology medicine.drug Antipsychotic Agents Tomography Emission-Computed |
| Zdroj: | Brain research. 768(1-2) |
| ISSN: | 0006-8993 |
| Popis: | Amisulpride, a benzamide derivative with an atypical neuroleptic profile relieves the negative symptoms of schizophrenia when administered at low doses (50–150 mg). In an attempt to define the anatomical substrates involved in this action we have studied the effects of amisulpride on regional cerebral glucose utilisation (RCGU) in the awake lightly restrained rat, by quantitative autoradiography using [14C]2-deoxyglucose ([14C]2-DG). Amisulpride was administered 1 h before [14C]2DG i.v. injection, at a dose of 5 mg/kg which resulted in a striatal D2 receptor occupancy of 10% similar to that induced by doses of this compound used for the treatment of negative symptoms of schizophrenia. Amisulpride induced significant RCGU increases in cortical areas, in visual relays, in auditory structures and in several limbic structures. The pattern of changes in RCGU seen with amisulpride clearly differs from that of haloperidol, given at a dose resulting in a similar occupancy of striatal D2 receptors (0.01 mg/kg), which was mostly ineffective. The amisulpride-induced activation of RCGU in specific brain areas involved in the control of cognitive functions and motivational and emotional behavior, may at least in part, explain the efficacy of this compound in the treatment of negative symptoms of schizophrenia. |
| Databáze: | OpenAIRE |
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