Antioxidant-rich Clitoria ternatea L. flower and its benefits in improving murine reproductive performance
| Autor: | P.J. Kwong, Chong Lee Ng, Kah-Yaw Ee, Shu En Goh, Wen-Jie Ng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Litter (animal)
endocrine system Antioxidant antioxidant Offspring DPPH medicine.medical_treatment medicine.disease_cause chemistry.chemical_compound bisphenol-A medicine T1-995 TX341-641 endocrine disrupting agent Technology (General) EC50 Pregnancy biology Traditional medicine Nutrition. Foods and food supply Clitoria ternatea biology.organism_classification medicine.disease edible flower chemistry C. ternatea Oxidative stress Food Science Biotechnology |
| Zdroj: | Food Science and Technology, Issue: ahead, Published: 09 JUL 2021 Food Science and Technology v.42 2022 Food Science and Technology (Campinas) Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) instacron:SBCTA Food Science and Technology (2021) Food Science and Technology, Volume: 42, Article number: e25921, Published: 09 JUL 2021 |
| Popis: | C. ternatea is often used as a natural food colouring besides improving the aesthetic value of foods. It contains various antioxidants and bioactive compounds, which exert many functions, such as counteracting oxidative stress, anti-proliferative and anti-inflammatory activities. This study evaluated the antioxidant activity of C. ternatea flower extract and its protective effect on bisphenol A (BPA)-induced oxidative injury in female murine reproductive system. DPPH free radical scavenging activity (EC50 12.47 ± 2.96 mg/mL) and total phenolic content (4.59 ± 0.09 mg GAE/g) of C. ternatea flower extract were determined. Then, Institute Cancer Research (ICR) dams were administered with BPA and/or C. ternatea extract for six weeks to study on uterine histomorphology, percentage of pregnancy and offspring development. It was found that the uterus weight to body weight ratio from dam co-administered with BPA and C. ternatea was lower than dam treated with BPA alone, although no histopathological effect was found. However, the percentage of pregnancy and litter size from C. ternatea-fed group were both higher compared to BPA-fed dam. In conclusion, C. ternatea extract showed high antioxidant activity and exert potential protective effects against BPA on the reproduction performance in terms of improving the percentage of pregnancy and litter size. |
| Databáze: | OpenAIRE |
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