Unveiling in Vivo Subcutaneous Thermal Dynamics by Infrared Luminescent Nanothermometers
| Autor: | W.Q. Santos, Luís D. Carlos, Blanca del Rosal, Carlos D. S. Brites, Artur S. Gouveia-Neto, Daniel Jaque, Carlos Jacinto, Agustín Martín Domingo, Francisco Sanz-Rodríguez, Uéslen Rocha, Upendra Kumar Kagola, Erving Ximendes, Nuria Fernández, David Bravo |
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| Rok vydání: | 2016 |
| Předmět: |
Ytterbium
CANCER-THERAPY TISSUES Luminescence Materials science Luminescent Measurements Infrared Rays Thermometers Infrared Nanoparticle chemistry.chemical_element 2ND BIOLOGICAL WINDOW Bioengineering Nanotechnology 02 engineering and technology QUANTUM DOTS Administration Cutaneous 010402 general chemistry CARBON NANOTUBES 01 natural sciences Body Temperature Mice Skin Physiological Phenomena FLUORESCENT NANOPARTICLES Animals General Materials Science DRUG-DELIVERY Neodymium Mechanical Engineering Doping OPTICAL-PROPERTIES General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Fluorescence 0104 chemical sciences chemistry UP-CONVERSION Nanoparticles ENERGY-TRANSFER 0210 nano-technology Biosensor |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 1530-6992 1530-6984 |
| DOI: | 10.1021/acs.nanolett.5b04611 |
| Popis: | The recent development of core/shell engineering of rare earth doped luminescent nanoparticles has ushered a new era in fluorescence thermal biosensing, allowing for the performance of minimally invasive experiments, not only in living cells but also in more challenging small animal models. Here, the potential use of active-core/active-shell Nd(3+)- and Yb(3+)-doped nanoparticles as subcutaneous thermal probes has been evaluated. These temperature nanoprobes operate in the infrared transparency window of biological tissues, enabling deep temperature sensing into animal bodies thanks to the temperature dependence of their emission spectra that leads to a ratiometric temperature readout. The ability of active-core/active-shell Nd(3+)- and Yb(3+)-doped nanoparticles for unveiling fundamental tissue properties in in vivo conditions was demonstrated by subcutaneous thermal relaxation monitoring through the injected core/shell nanoparticles. The reported results evidence the potential of infrared luminescence nanothermometry as a diagnosis tool at the small animal level. |
| Databáze: | OpenAIRE |
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