Stable Chromosome Aberrations in the Lymphocytes of a Population Living in the Vicinity of the Semipalatinsk Nuclear Test Site
| Autor: | Mustonen R, Zaure Zh. Mamyrbaeva, Rakhmetkaji I. Bersimbaev, Carita Lindholm, Yuri E. Dubrova, Koivistoinen A, Sisko Salomaa, Maj Hultén, Maira K. Tankimanova |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Radioactive Fallout Adolescent Population Biophysics Chromosomal translocation Biology Ionizing radiation medicine Humans Radiology Nuclear Medicine and imaging Lymphocytes education In Situ Hybridization Fluorescence Aged Chromosome Aberrations Genetics Sex Characteristics education.field_of_study Radiation medicine.diagnostic_test Smoking Age Factors Chromosome Translocation analysis Environmental Exposure Middle Aged Molecular biology Kazakhstan Regression Analysis Female Nuclear test Chromosome painting Fluorescence in situ hybridization |
| Zdroj: | Radiation Research. 158:591-596 |
| ISSN: | 1938-5404 0033-7587 |
| DOI: | 10.1667/0033-7587(2002)158[0591:scaitl]2.0.co;2 |
| Popis: | SalomaTranslocation analysis using FISH (fluorescence in situ hybridization) chromosome painting was performed to evaluate the magnitude of exposure to ionizing radiation among the human population living close to the Semipalatinsk nuclear test site in Kazakhstan. We studied two generations of people living in villages that were in the path of the radioactive cloud from the first Soviet surface nuclear test performed in August 1949 and from later tests. The older generation (P(0)) lived in the area at the time of testing, and the younger generation (F(1)) was exposed to smaller doses from the residual fallout and later tests. In both P(0) and F(1) generations, similar translocation frequencies were observed in persons living in either the Semipalatinsk area or a noncontaminated area. Assuming translocation stability in peripheral blood lymphocytes over several decades, these findings suggest that on average, the magnitude of exposure of this cohort in the Semipalatinsk area has been considerably smaller than that reported in the literature. Previously reported doses of the order of 1-4.5 Gy (mean 2.9 Gy in the P(0) generation) cannot be confirmed by the present data. |
| Databáze: | OpenAIRE |
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