Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene

Autor:	Jindřich Olšovský, Darja Krusová, Miluše Hertlová, Marta Kalousová, Kateřina Kaňková, Tomáš Zima
Rok vydání:	2008
Předmět:	Glycation End Products Advanced Male medicine.medical_specialty Physiology Receptor for Advanced Glycation End Products Renal function 030209 endocrinology & metabolism Enzyme-Linked Immunosorbent Assay 030204 cardiovascular system & hematology RAGE (receptor) Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Glycation Physiology (medical) Diabetes mellitus Internal medicine medicine Humans Diabetic Nephropathies Receptors Immunologic Receptor Aged business.industry Genetic Variation General Medicine Middle Aged medicine.disease Endocrinology Cross-Sectional Studies Haplotypes Albuminuria Female medicine.symptom business Kidney disease Glomerular Filtration Rate
Zdroj:	Archives of physiology and biochemistry. 114(2)
ISSN:	1381-3455
Popis:	Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of advanced glycation end products (AGEs) exerting their adverse effects via receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n = 94) or DN (n = 171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P = 0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P = 0.047). sRAGE did not correspond with carrier state of risk-haplotype copies (RAGE2) (P0.05). In conclusion, GFR is a principal determinant of sRAGE concentration and gradual sRAGE increase in subjects with advancing impairment of renal function is paralleled by AGEs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c989a0748679845134635b39b09ca90b https://pubmed.ncbi.nlm.nih.gov/18615900 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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