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Lin Wang,1 Ming-Hui Xin,1 Yan Ma,1 Yu Wang,1 Meng-Yuan Hu,1 Qiang-Qiang Liu,1 Jin-Bor Chen2,3 1Department of Nephrology, Dalian University Affiliated Xinhua Hospital, Dalian, Peopleâs Republic of China; 2Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan, Republic of China; 3School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of ChinaCorrespondence: Jin-Bor ChenDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, 123 Ta Pei Road, Niao Song District, Kaohsiung City, Taiwan, Republic of China, Tel +886-7-7317123, ext 8306, Fax +886-7-7322402, Email chenjb1019@gmail.comPurpose: There is a limited evidence of durable effect of parathyroidectomy (PTX) on the quality of life (QoL) in dialysis populations. We aimed to investigate this concern by comparing the QoL scores in the pre- and post-PTX periods in a cohort of dialysis patients.Patients and Methods: A total of 212 dialysis patients were enrolled in a hospital-facilitated dialysis center in China between July 1, 2016 and June 30, 2021. The mean age was 46.4 years; the male:female ratio was 96:116; hemodialysis 191, peritoneal dialysis 21. Informative data relating to demographics and dialysis were recorded for comparison. QoL was measured using the Chinese version of the Kidney Disease Quality of Life-36 (KDQOL-36â¢) and compared subscale scores between the pre-and post-PTX period. Appropriate statistical methods and Pearsonâs correlation test were used for statistical analysis.Results: Nutritional markers, including hemoglobin and albumin, significantly increased post-PTX than pre-PTX. KDQOL-36 domain scale scores, including Symptoms and Problems of Kidney Disease, Burden of Kidney Disease, Effects of Kidney Disease (EKD), Physical Component Summary (PCS) score, and Mental Component Summary score, significantly increased post-PTX than pre-PTX. All patients were further stratified into three groups based on the PTX durationâ 0â 2 years, > 2â< 5 years, and ⥠5 yearsâand all KDQOL-36 domain scale scores increased in individual PTX durations. The PTX duration showed a significant negative correlation between PCS subscale scores and a positive correlation between EKD subscale scores.Conclusion: PTX could improve QoL in dialysis patients with medically refractory secondary hyperparathyroidism. The durable effects should be studied using a larger sample.Keywords: dialysis, Kidney Disease Quality of Life-36, parathyroidectomy |
