Non-ulcerogenic pyrazolyl 2-hydroxychalcones and pyrazolylpyrazolines derived from naturally existing furochromone (khellin): semi-synthesis, docking study and anti-inflammatory activity
| Autor: | M. Alaraby Salem, Mamdouh Moawad Ali, Fatma A. Ragab, Yassin M. Nissan, Ahmed Abbass Mohamed Abd El-Rahman Selim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Khellin
Diclofenac Stereochemistry medicine.drug_class Anti-Inflammatory Agents Plant Science Pyrazole 01 natural sciences Biochemistry Anti-inflammatory Analytical Chemistry chemistry.chemical_compound Structure-Activity Relationship Docking (dog) medicine Animals Edema Cyclooxygenase 2 Inhibitors Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry Anti-Inflammatory Agents Non-Steroidal 0104 chemical sciences Rats Molecular Docking Simulation 010404 medicinal & biomolecular chemistry Celecoxib Cyclooxygenase 2 |
| Zdroj: | Natural product research. 36(10) |
| ISSN: | 1478-6427 |
| Popis: | Novel pyrazolyl 2-hydroxychalcone derivatives 3a–e and pyrazolylpyrazoline derivatives 4a–e and 5a–j derived from the naturally existing furochromone (Khellin) were synthesized and evaluated for th... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|