The effect of the β-emitting yttrium-90 citrate on the dose–response of dicentric chromosomes in human lymphocytes: a basis for biological dosimetry after radiosynoviorthesis
| Autor: | M. Haney, J. Pinkert, H.-J. Selbach, R. Klett, M. Voth, Ernst Schmid, F. J. Gildehaus |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Tritiated water Biophysics In Vitro Techniques Biology Injections Intra-Articular Dicentric chromosome chemistry.chemical_compound In vivo Organometallic Compounds Relative biological effectiveness Humans Dosimetry Citrates Lymphocytes Irradiation Radionuclide Imaging General Environmental Science Chromosome Aberrations Synovitis Radiation business.industry X-Rays Dose-Response Relationship Radiation Beta Particles Dose–response relationship chemistry Absorbed dose Radiopharmaceuticals Nuclear medicine business Monte Carlo Method Relative Biological Effectiveness |
| Zdroj: | Radiation and Environmental Biophysics. 45:93-98 |
| ISSN: | 1432-2099 0301-634X |
| DOI: | 10.1007/s00411-006-0045-4 |
| Popis: | The production of dicentric chromosomes in human lymphocytes by beta-particles of yttrium-90 (Y-90) was studied in vitro to provide a basis of biological dosimetry after radiosynoviorthesis (RSO) of persistent synovitis by intra-articular administration of yttrium-90 citrate colloid. Since the injected colloid may leak into the lymphatic drainage exposing other parts of the body to radiation, the measurement of biological damage induced by beta-particles of Y-90 is important for the assessment of radiation risk to the patients. A linear dose-response relationship (alpha = 0.0229 +/- 0.0028 dicentric chromosomes per cell per gray) was found over the dose range of 0.2176-2.176 Gy. The absorbed doses were calculated for exposure of blood samples to Y-90 activities from 40 to 400 kBq using both Monte Carlo simulation and an analytical model. The maximum low-dose RBE, the RBE(M) which is equivalent to the ratio of the alpha coefficients of the dose-response curves, is well in line with published results obtained earlier for irradiation of blood of the same donor with heavily filtered 220 kV X-rays (3.35 mm copper), but half of the RBE(M) relative to weakly filtered 220 kV X-rays. Therefore, it can be concluded that for estimating an absorbed dose during RSO by the technique of biological dosimetry, in vitro and in vivo data for the same radiation quality are necessary. |
| Databáze: | OpenAIRE |
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