Association of platelet-to-lymphocyte ratio with silent brain infarcts in patients with paroxysmal atrial fibrillation
| Autor: | Abdurrahman Tasal, Ozge Altintas, Talip Asil, Okkes Taha Kucukdagli, Elvin Niftaliyev |
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| Přispěvatelé: | 0-Belirlenecek, Altintas, O., Department of Neurology, Nigde Bor State Hospital, Neurology Clinic, Nigde, Turkey -- Tasal, A., Cardiology Clinic, Medicalpark Tarsus Hospital, Mersin, Turkey -- Niftaliyev, E., Medical Faculty, Department of Neurology, BezmiAlem Vakıf University, Istanbul, Turkey -- Kucukdagli, O.T., Emergency Clinic, Bakirkoy Dr. Sadi Konuk Education and Training Hospital, Mersin, Turkey -- Asil, T., Medical Faculty, Department of Neurology, BezmiAlem Vakıf University, Istanbul, Turkey, ASİL, Talip |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Cell Count 030204 cardiovascular system & hematology 0302 clinical medicine Risk Factors Atrial Fibrillation Stroke prevention Medicine Lymphocytes Prospective Studies Prospective cohort study Stroke medicine.diagnostic_test biology Paroxysmal atrial fibrillation Atrial fibrillation General Medicine Magnetic Resonance Imaging ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS C-Reactive Protein Neurology Erythrocyte sedimentation rate cardiovascular system Cardiology Population study Female InformationSystems_MISCELLANEOUS Blood Platelets Brain Infarction medicine.medical_specialty Cardioemboli 03 medical and health sciences Internal medicine Silent brain infarct Humans cardiovascular diseases Aged Retrospective Studies ALTINTAS O. TASAL A. NIFTALIYEV E. KUCUKDAGLI O. T. Asil T. -Association of platelet-to-lymphocyte ratio with silent brain infarcts in patients with paroxysmal atrial fibrillation- NEUROLOGICAL RESEARCH cilt.38 ss.753-758 2016 business.industry C-reactive protein ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS Retrospective cohort study Magnetic resonance imaging medicine.disease Platelet-to-lymphocyte ratio body regions ComputingMethodologies_PATTERNRECOGNITION ROC Curve biology.protein Neurology (clinical) business 030217 neurology & neurosurgery |
| Popis: | PubMed ID: 27456433 Objectives: In this study, we aimed to evaluate whether the inflammation as measured by increased platelet to lymphocyte ratio (PLR) predispose to silent infarcts in patients with paroxysmal atrial fibrillation (PAF). Methods: The present study investigated a total of 48 new diagnosed patients with PAF who had no signs of stroke. PLR, which was calculated as the ratio of the platelet count to the lymphocyte count, C-reactive protein and erythrocyte sedimentation rate were measured due to evaluate inflammatory state. Magnetic resonance imaging (MRI) was performed to evaluate the presence of silent brain infarcts (SBIs) in patients. We calculated CHA2DS2–VASc scores for stratifying the stroke risk of patients. Results: Among our study population, the mean age was 56.40 ± 8.99; 36 patients were female. The leading vascular risk factor was hypertension (45.8%). SBI was determined in 16 patients (33.3%) on MRI. It was found that a higher PLR is significantly associated with the presence of SBIs in patients with PAF (P = .001). High PLR group showed silent lesions predominantly multiple, greater than 5 mm, bilateral and in the subcortical region; though no statistically significant differences were found in each lesion areas (P = .214; P = .509; P = .746; P = .059, respectively). Of 16 patients who showed SBI, 1 (6.3%) patient had CHA2DS2–Vasc scores of 0; 7 (43.8%) patients had CHA2DS2–Vasc scores of 1; 6 (37.5%) patients had CHA2DS2 -Vasc scores of 2 and 2 (12.5%) patients had CHA2DS2–Vasc scores of 3. We did not find any significant relationship between CHA2DS2–Vasc scores and presence of SBI in the study patients (P = .850). Discussion: High PLR might be a factor to induce inflammatory process on SBIs even with low CHA2DS2–VASc scores. © 2016 Informa UK Limited, trading as Taylor & Francis Group. |
| Databáze: | OpenAIRE |
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