Dosimetric difference amongst 3 techniques: TomoTherapy, sliding-window intensity-modulated radiotherapy (IMRT), and RapidArc radiotherapy in the treatment of late-stage nasopharyngeal carcinoma (NPC)
| Autor: | Francis Kar-ho Lee, Ricky M. C. Chau, Celia Wai yi Yip, Alex K.C. Leung, Roger K.C. Ngan, Frankie Chun hung Cheung |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Organs at Risk medicine.medical_specialty medicine.medical_treatment Risk Assessment Sensitivity and Specificity Tomotherapy Radiation Protection otorhinolaryngologic diseases medicine Humans Radiology Nuclear Medicine and imaging Stage (cooking) Neoplasm Staging Monitor unit Radiological and Ultrasound Technology business.industry Radiotherapy Planning Computer-Assisted Late stage Reproducibility of Results Nasopharyngeal Neoplasms Radiotherapy Dosage medicine.disease Radiation therapy Target dose Treatment Outcome Oncology Nasopharyngeal carcinoma Female Intensity modulated radiotherapy Radiology Radiotherapy Intensity-Modulated business Nuclear medicine |
| Zdroj: | Medical dosimetry : official journal of the American Association of Medical Dosimetrists. 39(1) |
| ISSN: | 1873-4022 |
| Popis: | To investigate the dosimetric difference amongst TomoTherapy, sliding-window intensity-modulated radiotherapy (IMRT), and RapidArc radiotherapy in the treatment of late-stage nasopharyngeal carcinoma (NPC). Ten patients with late-stage (Stage III or IV) NPC treated with TomoTherapy or IMRT were selected for the study. Treatment plans with these 3 techniques were devised according to departmental protocol. Dosimetric parameters for organ at risk and treatment targets were compared between TomoTherapy and IMRT, TomoTherapy and RapidArc, and IMRT and RapidArc. Comparison amongst the techniques was done by statistical tests on the dosimetric parameters, total monitor unit (MU), and expected delivery time. All 3 techniques achieved similar target dose coverage. TomoTherapy achieved significantly lower doses in lens and mandible amongst the techniques. It also achieved significantly better dose conformity to the treatment targets. RapidArc achieved significantly lower dose to the eye and normal tissue, lower total MU, and less delivery time. The dosimetric advantages of the 3 techniques were identified in the treatment of late-stage NPC. This may serve as a guideline for selection of the proper technique for different clinical cases. |
| Databáze: | OpenAIRE |
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