A Comparative Study of the Duration and Efficacy of Tetracaine 1% and Bupivacaine 0.75% in Controlling Pain following Photorefractive Keratectomy (PRK)
| Autor: | Melanie C. Corbett, A Patmore, John Marshall, G. Heacock, Seema Verma |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Visual acuity medicine.medical_treatment Visual Acuity law.invention Cornea 0302 clinical medicine Randomized controlled trial law Myopia Prospective Studies Anesthetics Local Prospective cohort study Pain Measurement Pain Postoperative medicine.diagnostic_test Local anesthetic Epithelium Corneal General Medicine Middle Aged Corneal topography Bupivacaine Photorefractive keratectomy Anesthesia Female Lasers Excimer medicine.symptom medicine.drug Adult medicine.medical_specialty Tetracaine medicine.drug_class Photorefractive Keratectomy 03 medical and health sciences Double-Blind Method Ophthalmology medicine Humans Aged Wound Healing business.industry Corneal Topography 030221 ophthalmology & optometry Ophthalmic Solutions business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | European Journal of Ophthalmology. 7:327-333 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/112067219700700404 |
| Popis: | ObjectiveTo evaluate if topical bupivacaine 0.75% provides better pain control after excimer laser over topical tetracaine 1% without affecting corneal wound healing, refractive outcome of visual function.DesignA prospective, double-masked trial was conducted in which 38 patients were randomized to receive either tetracaine or bupivacaine every 30 minutes for 24 hours post-operatively. Pain was recorded over a four day period using a Visual Analogue Pain Scale. The rate of epithelial healing was assessed during digitized retro-illumination photography. Visual performance was recorded using best corrected Snellen acuity, objective measurements of haze, halo and glare over a six month period.ResultsTetracaine afforded better pain control (p=0.05). Full epithelial closure occurred in all patients within 72 hours and no statistically significant difference was recorded in any of the parameters measured.ConclusionsContrary to our expectation, the longer acting anaesthetic, bupivacaine, was inferior to tetracaine. Limited and supervised use of topical anaesthetics is recommended in controlling pain following photorefractive keratectomy. |
| Databáze: | OpenAIRE |
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