Pharmacodynamic effects of 51W89, an isomer of atracurium, in children during halothane anaesthesia
| Autor: | O. A. Meretoja, T. Taivainen, K. Wirtavuoria |
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| Rok vydání: | 1995 |
| Předmět: |
Blood Pressure
Drug Administration Schedule Isomerism Pharmacokinetics Heart Rate Heart rate Atracurium besilate Humans Medicine Child Dose-Response Relationship Drug Electromyography business.industry Halothane anaesthesia Neostigmine Adductor pollicis muscle Anesthesiology and Pain Medicine Blood pressure Child Preschool Pharmacodynamics Anesthesia Atracurium Neuromuscular Blocking Agents Halothane Anesthesia Inhalation business medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 74:6-11 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/74.1.6 |
| Popis: | 51W89 is one of the 10 stereoisomers of atracurium with less propensity to release histamine than atracurium. We evaluated dose-response data and neuromuscular effects of 2 × ED 95 dose and maintenance doses of 51W89 during halothane anaesthesia in 68 children, 2–12 yr old. Neuromuscular function was monitored by evoked adductor pollicis EMG. Log-probit, single-dose, dose-response data gave ED 50 and ED 95 values of 23 and 41 μg kg −1 , respectively, for 51W89. Twice the ED 95 dose (80μgkg −1 ) had an onset time (time from administration to maximum effect) of 2.5 (SD 0.8) min, a clinical duration (time to 25% EMG recovery) of 31 (7) min and a recovery index (time from 25 to 75% EMG recovery) of 11.1 (1.7) min. Seventy-nine incremental doses of 51W89 of 0.5 × ED 95 dose were given in 16 children at 85–90% neuromuscular block. The mean duration of these doses was 13.4 (3) min, with a calculated hourly maintenance requirement of 51W89 of 94 (19) μg kg −1 . Duration of effect of incremental doses remained constant within individuals reflecting non-cumulative properties. There were insignificant changes in arterial pressure and heart rate after 51W89 and no side effects were observed. We regard 51W89 as a promising, non-cumulative, intermediate-acting neuromuscular.blocking agent the effects of which can be antagonized easily by neostigmine. |
| Databáze: | OpenAIRE |
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