Long-term prognostic role of CA-125 in noncongestive patients undergoing a cardiac transplantation
| Autor: | Víctor Manuel Becerra-Muñoz, Diego Rangel-Sousa, José Manuel García-Pinilla, E. Lage-Gallé, Eduardo de Teresa-Galván, José Manuel Sobrino-Márquez, Ángel Martínez-Martínez, Agustín Fernández-Cisnal |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Clinical Biochemistry 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine Drug Discovery Odds Ratio medicine Humans 030212 general & internal medicine Retrospective Studies Heart Failure Graft rejection business.industry Biochemistry (medical) Middle Aged Prognosis medicine.disease Surgery Survival Rate Transplantation CA-125 Antigen Heart failure Cardiology Heart Transplantation Female business Biomarkers Follow-Up Studies |
| Zdroj: | Biomarkers in Medicine. 11:239-243 |
| ISSN: | 1752-0371 1752-0363 |
| DOI: | 10.2217/bmm-2016-0247 |
| Popis: | Aim: To evaluate the possible relationship between high levels of CA-125 and long-term prognosis in chronic heart failure patients after they undergo a cardiac transplantation (CT). Materials & methods: We retrospectively studied all patients who underwent a CT and had a previous determination of CA-125. Congestive patients and those whose survival was 35 U/ml). After CT, survival was significantly inferior in this group (96.3 vs 81%, 84.9 vs 64%, 70.7 vs 32.9% at 2, 5 and 8 years, p = 0.014). CA-125 >35 U/ml was the only factor independently associated to long-term mortality (OR: 3.94; 95% CI: 1.2–12.82; p = 0.023). Conclusion: Noncongestive patients with high levels of CA-125 had inferior long-term survival after CT. |
| Databáze: | OpenAIRE |
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