Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and risk of HIV/AIDS among North Indian population
| Autor: | Ajay Wanchu, Seyed Ali Hosseini, Salih Abdul Mahedi, Ranbir Chander Sobti, Nega Berhane, Rupinder Kler, Vijish Kuttiat |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Genotype DNA Mutational Analysis Clinical Biochemistry India Polymorphism Single Nucleotide law.invention Gene Frequency Acquired immunodeficiency syndrome (AIDS) Risk Factors law Genetic variation medicine Humans Genetic Predisposition to Disease Allele Interleukin 6 Molecular Biology Gene Polymerase chain reaction Acquired Immunodeficiency Syndrome biology Interleukin-6 Cell Biology General Medicine Middle Aged medicine.disease Virology Interleukin-10 Case-Control Studies Immunology Disease Progression HIV-1 biology.protein Female Restriction fragment length polymorphism Polymorphism Restriction Fragment Length |
| Zdroj: | Molecular and Cellular Biochemistry. 337:145-152 |
| ISSN: | 1573-4919 0300-8177 |
| Popis: | A growing body of evidence suggests that host genetic factors play an important role both in susceptibility to HIV infection and progression to AIDS. The present study aimed at evaluating the role of IL-6 and IL-10 gene polymorphisms on the risk of HIV susceptibility and disease progression among North Indian patients. The polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques were applied to genotype IL-6 and IL-10. 300 seropositive and an equal number of age- and sex-matched seronegative control subjects were recruited for this study. There was statistically no significant variation in the frequencies of IL-6 and IL-10 genotypes among cases and controls. However, statistically non-significant association for risk of rapid disease progression was observed due to the combined effect of the IL-6 homozygous CC genotype and CC of IL-10, OR = 1.62, 95% CI = 0.38-6.91. Therefore, combined effects of the CC of IL-6 and CC of IL-10 might reduce the hosts ability to hinder viral replication after infection. |
| Databáze: | OpenAIRE |
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