Language dominance in children as determined by magnetic source imaging and the intracarotid amobarbital procedure: a comparison
| Autor: | Joshua I. Breier, Vijayalakshmi Venkataraman, Andrew C. Papanicolaou, Panagiotis G. Simos, Jules E. C. Constantinou, James E. Baumgartner, James W. Wheless |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Amobarbital Audiology Neuropsychological Tests Lateralization of brain function 03 medical and health sciences Epilepsy 0302 clinical medicine Predictive Value of Tests 030225 pediatrics medicine Humans Child Dominance Cerebral GABA Modulators Evoked Potentials Recognition memory Language Brain Mapping Magnetoencephalography medicine.disease Functional imaging Magnetic source imaging Injections Intra-Arterial Pediatrics Perinatology and Child Health Laterality Female Neurology (clinical) Psychology 030217 neurology & neurosurgery Intractable seizures medicine.drug Cognitive psychology |
| Zdroj: | Journal of child neurology. 16(2) |
| ISSN: | 0883-0738 |
| Popis: | This study evaluated the validity of data derived from magnetic source imaging regarding hemispheric dominance for language in children and adolescents with intractable seizure disorder by comparison with results of the intracarotid amobarbital procedure. Functional imaging of the receptive language cortex using a whole-head neuromagnetometer was performed in 19 consecutive epilepsy patients, ages 8 to 18 years, who also underwent the intracarotid amobarbital procedure. During magnetic source imaging recordings, patients engaged in a continuous recognition memory task for words in visual and auditory modalities. This task has previously been shown to be valid for the purpose of lateralization and localization of language cortex in adult epilepsy patients who undergo the intracarotid amobarbital procedure and intraoperative language mapping allowing confirmation of magnetic source imaging findings. Results indicated that language laterality indices formed for the intracarotid amobarbital procedure and magnetic source imaging procedures were highly correlated (R = .87). In addition, clinical judgments regarding cerebral dominance for language made by independent raters using the two methods were in excellent agreement. We conclude that magnetic source imaging is a promising method for determination of cerebral dominance for language in children and adults. (J Child Neurol 2001;16:124-130). |
| Databáze: | OpenAIRE |
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