Quantitative T2, T2*, and T2′ MR imaging in patients with ischemic leukoaraiosis might detect microstructural changes and cortical hypoxia
| Autor: | Oliver C. Singer, Steffen Volz, Ralf Deichmann, Luciana Porto, Michael Helfrich, Jörg Magerkurth, Elke Hattingen, Marlies Wagner, Stella Blasel, Alina Jurcoane |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Sensitivity and Specificity Brain Ischemia Brain ischemia White matter Atrophy Humans Medicine Radiology Nuclear Medicine and imaging Gray Matter Aged Neuroradiology Aged 80 and over medicine.diagnostic_test business.industry Leukoaraiosis Brain Reproducibility of Results Magnetic resonance imaging Middle Aged Hypoxia (medical) medicine.disease Magnetic Resonance Imaging White Matter Oxygen medicine.anatomical_structure Cerebral blood flow Cerebrovascular Circulation Female Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine business Blood Flow Velocity |
| Zdroj: | Neuroradiology. 57:1023-1030 |
| ISSN: | 1432-1920 0028-3940 |
| DOI: | 10.1007/s00234-015-1565-x |
| Popis: | Quantitative MRI with T2, T2*, and T2′ mapping has been shown to non-invasively depict microstructural changes (T2) and oxygenation status (T2* and T2′) that are invisible on conventional MRI. Therefore, we aimed to assess whether T2 and T2′ quantification detects cerebral (micro-)structural damage and chronic hypoxia in lesions and in normal appearing white matter (WM) and gray matter (GM) of patients with ischemic leukoaraiosis (IL). Measurements were complemented by the assessment of the cerebral blood flow (CBF) and the degree of GM and WM atrophy. Eighteen patients with IL and 18 age-matched healthy controls were included. High-resolution, motion-corrected T2, T2*, and T2′ mapping, CBF mapping (pulsed arterial spin labeling, PASL), and segmentation of GM and WM were used to depict specific changes in both groups. All parameters were compared between patients and healthy controls, using t testing. Values of p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink