Numerical Sex Chromosome Aberrations and Abnormal Sex Development in Horse and Sheep
| Autor: | D. Crocco, Alessandra Iannuzzi, Pietro Parma, Leopoldo Iannuzzi, Gianluca Neglia, V. Genualdo, Domenico Incarnato, Angela Perucatti, G.P. Di Meo, G. Romano |
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| Přispěvatelé: | Di Meo, G. P., Neglia, Gianluca, Perucatti, A., Genualdo, V., Iannuzzi, A., Crocco, D., Incarnato, D., Romano, G., Parma, P., Iannuzzi, L. |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Embryology medicine.medical_specialty Monosomy Endocrinology Diabetes and Metabolism Disorders of Sex Development Physiology Gonadal dysgenesis Clitoris Biology Horse C-Banding Sex chromosome anomaly Sex development Sheep Vulva Sexual Behavior Animal medicine Animals Horses Metaphase Sex Chromosome Aberrations X chromosome Cytogenetics Chromosome Karyotype Anatomy medicine.disease Chromosome Banding medicine.anatomical_structure Female Developmental Biology |
| Zdroj: | Sexual development 3 (2009): 329–332. doi:10.1159/000279289 info:cnr-pdr/source/autori:Di Meo GP, Neglia G, Perucatti A, Genualdo V, Iannuzzi A, Crocco D, Incarnato D, Romano G, Parma P, Iannuzzi L/titolo:Numerical Sex Chromosome Aberrations and Abnormal Sex Development in Horse and Sheep./doi:10.1159%2F000279289/rivista:Sexual development (Print)/anno:2009/pagina_da:329/pagina_a:332/intervallo_pagine:329–332/volume:3 |
| Popis: | Gonadal dysgenesis and heterosexual conditions are often associated with sex chromosome abnormalities. In this study we report on 2 cases of abnormal sex development involving numerical sex chromosome aberrations in both horse and sheep. A 17-month-old Standardbred filly was sent to an equine fertility centre as an embryo donor due to its reduced size, being much smaller than a racehorse filly of the same age, which excluded it from an athletic career. External genitalia were clinically normal but manual palpation of the reproductive tract showed the presence of a small underdeveloped uterus and ovaries, as confirmed by ultrasonographic examination. Cytogenetic investigation by CBA-banding revealed an abnormal karyotype with X chromosome monosomy (2n = 63,X). A 18-month-old ewe showed distinct heterosexual traits with presence of a vulva (with enlarged clitoris), well-developed abdominal testes and mammary glands. Internal sex adducts were atrophic as seen after mating. Cytogenetic analysis revealed the presence of XX/XY mosaicism. |
| Databáze: | OpenAIRE |
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