NMR-Based Metabolomics Profiling for Radical Scavenging and Anti-Aging Properties of Selected Herbs
| Autor: | Ahmad Haniff Jaafar, Faridah Abas, Suri Roowi, Nordiana Abdul Majid, Mohd Sabri Pak Dek, Nurul Shazini Ramli, Mahanom Hussin, Azizah Abdul Hamid |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
multivariate data analysis
Magnetic Resonance Spectroscopy Oxygen radical absorbance capacity DPPH Pharmaceutical Science elastase inhibitor 01 natural sciences Pluchea indica Article Analytical Chemistry collagenase inhibitor lcsh:QD241-441 chemistry.chemical_compound 0404 agricultural biotechnology lcsh:Organic chemistry Drug Discovery Physical and Theoretical Chemistry Isorhamnetin Flavonoids radical scavenging ABTS Plants Medicinal Traditional medicine biology compound profiling Organic Chemistry Cosmos caudatus 04 agricultural and veterinary sciences biology.organism_classification 040401 food science Quercitrin metabolomics 0104 chemical sciences 010404 medicinal & biomolecular chemistry proton NMR chemistry Chemistry (miscellaneous) Multivariate Analysis Molecular Medicine Quercetin |
| Zdroj: | Molecules, Vol 24, Iss 17, p 3208 (2019) Molecules Volume 24 Issue 17 |
| ISSN: | 1420-3049 |
| Popis: | Herbs that are usually recognized as medicinal plants are well known for their therapeutic effects and are traditionally used to treat numerous diseases, including aging. This study aimed to evaluate the metabolite variations among six selected herbs namely Curcurma longa, Oenanthe javanica, Vitex negundo, Pluchea indica, Cosmos caudatus and Persicaria minus using proton nuclear magnetic resonance (1H-NMR) coupled with multivariate data analysis (MVDA). The free radical scavenging activity of the extract was measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azinobis(3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) and oxygen radical absorbance capacity (ORAC) assay. The anti-aging property was characterized by anti-elastase and anti-collagenase inhibitory activities. The results revealed that P. minus showed the highest radical scavenging activities and anti-aging properties. The partial least squares (PLS) biplot indicated the presence of potent metabolites in P. minus such as quercetin, quercetin-3-O-rhamnoside (quercitrin), myricetin derivatives, catechin, isorhamnetin, astragalin and apigenin. It can be concluded that P. minus can be considered as a potential source for an anti-aging ingredient and also a good free radical eradicator. Therefore, P. minus could be used in future development in anti-aging researches and medicinal ingredient preparations. |
| Databáze: | OpenAIRE |
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