No benefit from adding GM-CSF to induction chemotherapy in transforming myelodysplastic syndromes: better outcome in patients with less proliferative disease

Autor:	Jon-Magnus Tangen, Herman Nilsson-Ehle, Eva Hellström-Lindberg, Ingemar Winquist, Ulf Tidefelt, Robert Hast, Olle Linder, G. Gahrton, Inger Marie S. Dahl, Ingela Turesson, L Ohm, Per Bernell, Gunnar Öberg, C. Paul, Jonas Wallvik, Magnus Björkholm, Richard Lerner, Fredrik Celsing, Greger Lindberg, Eva Löfvenberg, J. Samuelsson, Anders Wahlin, I. Dybedal
Rok vydání:	2003
Předmět:	Adult Male Cancer Research medicine.medical_specialty medicine.medical_treatment Gastroenterology Internal medicine Multicenter trial Antineoplastic Combined Chemotherapy Protocols medicine Humans Prospective Studies Thioguanine Prospective cohort study Survival rate Aged Aged 80 and over Chemotherapy Anemia Refractory with Excess of Blasts business.industry Myelodysplastic syndromes Daunorubicin Remission Induction Cytarabine Granulocyte-Macrophage Colony-Stimulating Factor Induction chemotherapy Hematology Middle Aged medicine.disease Surgery Survival Rate Regimen Cell Transformation Neoplastic Oncology Leukemia Myeloid International Prognostic Scoring System Myelodysplastic Syndromes Acute Disease Female business Follow-Up Studies
Zdroj:	Leukemia. 17:1827-1833
ISSN:	1476-5551 0887-6924
Popis:	In this prospective randomized multicenter trial 93 patients, median age 72 years, with RAEB-t (n=25) and myelodysplastic syndrome (MDS)-AML (n=68) were allocated to a standard induction chemotherapy regimen (TAD 2+7) with or without addition of granulocyte-macrophage-CSF (GM-CSF). The overall complete remission (CR) rate was 43% with no difference between the arms. Median survival times for all patients, CR patients, and non-CR patients were 280, 550, and 100 days, respectively, with no difference between the arms. Response rates were significantly better in patients with serum lactate dehydrogenase (S-LDH) levels
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9728f4bad2cb7ff775acf81abd58c98 https://doi.org/10.1038/sj.leu.2403035 Zobrazit plný text záznamu Plný text ve formátu PDF