Iron therapy, advanced oxidation protein products, and carotid artery intima-media thickness in end-stage renal disease
| Autor: | Z A Massy, Tilman B. Drüeke, Véronique Witko-Sarsat, Alain P. Guerin, Valérie Gausson, Gérard M. London, S. J. Marchais, Béatrice Descamps-Latscha |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Carotid Artery Diseases
Male medicine.medical_specialty Pathology Carotid Artery Common medicine.medical_treatment Iron medicine.disease_cause Gastroenterology End stage renal disease Cohort Studies Renal Dialysis Risk Factors Physiology (medical) Internal medicine medicine.artery medicine Humans cardiovascular diseases Common carotid artery Ultrasonography Dose-Response Relationship Drug business.industry Proteins Middle Aged medicine.disease Oxidative Stress Blood chemistry Intima-media thickness Advanced oxidation protein products Ferritins Multivariate Analysis cardiovascular system Kidney Failure Chronic Female Hemodialysis Cardiology and Cardiovascular Medicine business Tunica Intima Tunica Media Oxidative stress Biomarkers Kidney disease |
| Zdroj: | Circulation. 106(17) |
| ISSN: | 1524-4539 |
| Popis: | Background—Increased common carotid artery intima-media thickness (CCA-IMT) is a marker of early atherosclerosis. Low-grade inflammation is associated with the pathogenesis of atherosclerosis. Low-grade inflammation and increased CCA-IMT are observed in end-stage renal disease (ESRD). Oxidative stress is involved in uremia-related inflammation. Advanced oxidation protein products (AOPP) are markers of oxidant-mediated protein damage in ESRD. Intravenous iron given to patients on hemodialysis (HD) might induce oxidative stress. We investigated the relationships between AOPP, iron therapy, and CCA-IMT in stable HD patients.Methods and Results—Plasma AOPP and blood chemistry, including iron status, were analyzed in a cohort of 79 ESRD patients on HD. Measurements of CCA-IMT and CCA diameter, as assessed by B-mode ultrasonography, were obtained in 60 patients. AOPP levels were elevated in ESRD patients, and in univariate (r=0.42,Pr=0.38,PPPP=0.0197) and CCA wall-to-lumen ratio (r=0.560,PP=0.015) in patients Conclusion—In ESRD patients, CCA-IMT and CCA wall-to-lumen ratio were associated with plasma AOPP, serum ferritin, and the annual intravenous iron dose administered. These findings support the concept of a role of oxidative stress in the early atherosclerosis of ESRD patients, which may be increased by the usually recommended doses of intravenous iron. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|