A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Livers
| Autor: | Elizaveta V Starikova, Denis A Gudkov, Irina D. Strazhesko, Olga N. Tkacheva, Nataliya S Klimenko, Oksana E. Glushchenko, Daria A. Kashtanova |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
food.ingredient Veillonellaceae Physiology microbiome Gut flora Coriobacteriaceae digestive system Microbiology Coprococcus Article 03 medical and health sciences food longevity Virology Medicine Microbiome lcsh:QH301-705.5 beneficial bacteria 030304 developmental biology Bifidobacterium 0303 health sciences biology gut microbiota 030306 microbiology business.industry aging systemic low-grade inflammation biology.organism_classification lcsh:Biology (General) Cohort long-livers business Ruminococcaceae |
| Zdroj: | Microorganisms Volume 8 Issue 8 Microorganisms, Vol 8, Iss 1162, p 1162 (2020) |
| ISSN: | 2076-2607 |
| Popis: | The aim was to assess the gut microbiota of long-livers from Moscow. This study included two groups of patients who signed their consent to participate. The group of long-livers (LL) included 20 participants aged 97&ndash 100 years (4 men and 16 women). The second group included 22 participants aged 60&ndash 76 years (6 men) without clinical manifestations of chronic diseases (healthy elderly). Gut microbiota was studied by 16S rRNA sequencing. Long-livers underwent a complex geriatric assessment as well as expanded blood biochemistry. Gut microbiota composition in the cohorts was also compared with microbiome in long-livers from Japan and Italy. Russian long-livers&rsquo microbiome contained more beneficial bacteria than healthy elderly including Ruminococcaceae, Christensenellaceae, Lactobacillaceae families. Conditional pathogens like Veillonellaceae, Mogibacteriaceae, Alcaligenaceae, Peptococcaceae, Peptostreptococcaceae were more abundant in the healthy elderly. Compared with Italian and Japanese microbiome LL, the Russian LL appeared to be more similar to the Italian cohort. Bifidobacterium/Coprococcus and Faecalibacterium/Coprococcus balances were associated with femoral and carotid intima&ndash media thickness, respectively. Bifidobacterium/Coriobacteriaceae balance was assessed with the folic acid level and Faecalibacterium/Coriobacteriaceae_u the with Mini Nutritional Assessment score. Long-livers&rsquo microbiome appeared to be unexpectedly balanced. The high representation of beneficial bacteria in long-livers may prevent them from low-grade inflammation and thus protect them from the development of atherosclerosis and other aging-associated conditions. |
| Databáze: | OpenAIRE |
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