Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin

Autor:	Angel Lanas, Nicholas J. Talley, Michael Singh, S Appelman-Eszczuk, Bjorn E Eriksson, Rahim Daneshjoo, Neville D. Yeomans, Jorgen Naesdal, Maeve M Skelly, Pedro Serrano, Göran Långström, Christopher J. Hawkey, Alan B. R. Thomson
Rok vydání:	2005
Předmět:	Male medicine.medical_specialty Population Prevalence Asymptomatic Risk Assessment Endoscopy Gastrointestinal Risk Factors Internal medicine Epidemiology medicine Humans Pharmacology (medical) Stomach Ulcer education Aged Aspirin education.field_of_study Hepatology business.industry Incidence (epidemiology) Incidence Gastroenterology Odds ratio Middle Aged Surgery Duodenal Ulcer Platelet aggregation inhibitor Female medicine.symptom business Platelet Aggregation Inhibitors medicine.drug
Zdroj:	Alimentary pharmacologytherapeutics. 22(9)
ISSN:	0269-2813
Popis:	Summary Background : Aspirin is valuable for preventing vascular events, but information about ulcer frequency is necessary to inform risk-benefit decisions in individual patients. Aim : To determine ulcer prevalence and incidence in a population representative of those given aspirin therapy and evaluate risk predictors. Methods : Patients taking aspirin 75–325 mg daily were recruited from four countries. Exclusions included use of gastroprotectant drugs or other non-steroidal anti-inflammatory drugs. We measured point prevalence of endoscopic ulcers, after quantitating dyspeptic symptoms. Incidence was assessed 3 months later in those eligible to continue (no baseline ulcer or reason for gastroprotectants). Results : In 187 patients, ulcer prevalence was 11% [95% confidence interval (CI) 6.3–15.1%]. Only 20% had dyspeptic symptoms, not significantly different from patients without ulcer. Ulcer incidence in 113 patients followed for 3 months was 7% (95% CI 2.4–11.8%). Helicobacter pylori infection increased the risk of a duodenal ulcer [odds ratio (OR) 18.5, 95% CI 2.3–149.4], as did age >70 for ulcers in stomach and duodenum combined (OR 3.3, 95% CI 1.3–8.7). Conclusions : Gastroduodenal ulcers are found in one in 10 patients taking low-dose aspirin, and most are asymptomatic; this needs considering when discussing risks/benefits with patients. Risk factors include older age and H. pylori (for duodenal ulcer).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97166d8a96db44f8ab62d5d5cad46d1 https://pubmed.ncbi.nlm.nih.gov/31850568 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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