Telomerase activity in the differential diagnosis of pancreatic mass

Autor:	Alexey A Yushkevich, Ksenia S Russkova, Tatyana Degtyarevskaya, Arthur A Tevosyan, R.V. Karpova, V. V. Levkin
Rok vydání:	2019
Předmět:	Telomerase medicine.diagnostic_test business.industry Gastroenterology Cancer medicine.disease Oncology Pancreatic cancer Biopsy Pancreatic mass medicine Cancer research Original Article Differential diagnosis business Surgical treatment
Zdroj:	Journal of Gastrointestinal Oncology. 10:1094-1098
ISSN:	2219-679X 2078-6891
Popis:	BACKGROUND: In this manuscript, we show that the detection of telomerase activity in pancreatic mass tissue provides early evidence of a cancerous process that requires a well-timed surgical treatment. METHODS: Eighty-eight patients with pancreatic mass (both benign and malignant) were involved in the research. Comparative analyses of the data and instrumental methods to define the histological structure of tumor mass and measure telomerase activity have been carried out. RESULTS: Intense telomerase activity (+++) in the tissue of pancreatic mass determines cancer with high accuracy. One hundred percent of patients with pancreatic cancer had high telomerase activity. In 32.4% of patients with average telomerase activity (++) pancreatic cancer was diagnosed. The average telomerase activity (++) in pancreatic tumors gives an early indication of pancreatic cancer and requires dynamic observation for 6 to 12 months (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96e31f169d209eb445ecd51fe332d58 https://doi.org/10.21037/jgo.2019.08.07 Zobrazit plný text záznamu