Is ovarian relaxin a stimulus to placental protein 14 secretion in pregnancy?
| Autor: | D L Healy, T Chard, H O D Critchley |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Pregnancy Proteins Biology Stimulus (physiology) law.invention Endocrinology Double-Blind Method Randomized controlled trial Pregnancy law Internal medicine medicine Humans Secretion Labor Induced Glycoproteins Relaxin Labor Obstetric Term pregnancy Postpartum Period Placental protein medicine.disease Recombinant Proteins Stimulation Chemical Glycodelin Gestation Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Endocrinology. 142:375-378 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.1420375 |
| Popis: | The objective of this study was to investigate whether relaxin might be involved in placental protein 14 (PP14) secretion by measuring serum levels of PP14 during labour and post partum in normal women with a term pregnancy given vaginal human recombinant relaxin (rhRlx) gel for induction of labour. A randomized double-blind controlled trial was conducted on 11 women with a singleton pregnancy at term admitted for induction of labour. Comparison of serum PP14 and relaxin concentrations in the control and treated groups of subjects revealed that there was an increase in serum relaxin concentrations in women receiving 3 mg or 6 mg relaxin. There was no difference in serum PP14 levels between the control and treatment groups. These findings do not support the hypothesis that relaxin is involved in the control of PP14 secretion. However, the failure of any response might be a consequence of the very small increase in systemic levels of relaxin produced by topical vaginal administration of rhRlx. Furthermore, these measurements were made in late pregnancy and hence may not relate to the events in early pregnancy, when serum levels of PP14 are maximal. Journal of Endocrinology (1994) 142, 375–378 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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