Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors
| Autor: | Judith A. Stolwijk, Susanne Wallner, Stephan Schreml, Christoph Brochhausen, Wybke Klatt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Skin Neoplasms ddc:540 Cell 610 Medizin lcsh:Medicine Cell Cycle Proteins Nerve Tissue Proteins Article Metastasis Receptors G-Protein-Coupled 03 medical and health sciences 0302 clinical medicine Medical research medicine Carcinoma Humans Basal cell carcinoma Neoplasms Squamous Cell lcsh:Science Melanoma Nevus Cancer ddc:610 Multidisciplinary integumentary system Chemistry lcsh:R medicine.disease Receptors Neurotransmitter 030104 developmental biology medicine.anatomical_structure Tumor progression Carcinoma Basal Cell Tissue Array Analysis 030220 oncology & carcinogenesis 540 Chemie Cancer research lcsh:Q Skin cancer Ovarian cancer |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) |
| ISSN: | 2045-2322 |
| Popis: | The proton-sensing GPCRs (pH-GPCRs) GPR4 (GPR19), TDAG8 (GPR65, T-cell death associated gene 8), OGR1 (GPR68, ovarian cancer GPCR1), and G2A (GPR132, G2 accumulation protein) are involved in sensing and transducing changes in extracellular pH (pHe). Extracellular acidification is a central hallmark of solid cancer. pH-GPCR function has been associated with cancer cell proliferation, adhesion, migration and metastasis, as well as with modulation of the immune system. Little is known about the expression levels and role of pH-GPCRs in skin cancer. To better understand the functions of pH-GPCRs in skin cancer in vivo, we examined the expression-profiles of GPR4, TDAG8, OGR1 and G2A in four common skin tumors, i.e. squamous cell carcinoma (SCC), malignant melanoma (MM), compound nevus cell nevi (NCN), basal cell carcinoma (BCC). We performed immunohistochemistry and immunofluorescence staining on paraffin-embedded tissue samples acquired from patients suffering from SCC, MM, NCN or BCC. We show the expression of pH-GPCRs in four common skin cancers. Different expression patterns in the investigated skin cancer types indicate that the different pH-GPCRs may have distinct functions in tumor progression and serve as novel therapeutic targets. |
| Databáze: | OpenAIRE |
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