Determination of common organophosphorus pesticides in the blood of children with acute leukaemia using a double-solvent system as a novel extractant for dispersive liquid-liquid microextraction
| Autor: | Nazir Fattahi, Mohammad Reza Golpayegani, Farshad Fattahi, Reza Akramipour, Mostafa Sedighi |
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| Rok vydání: | 2020 |
| Předmět: |
Detection limit
Solvent system Analyte Chromatography Trace Amounts Chemistry Calibration curve General Chemical Engineering 010401 analytical chemistry Extraction (chemistry) General Chemistry 010501 environmental sciences 01 natural sciences 0104 chemical sciences Liquid liquid Organophosphorus pesticides 0105 earth and related environmental sciences |
| Zdroj: | RSC advances. 10(73) |
| ISSN: | 2046-2069 |
| Popis: | In this research, a new mode of dispersive liquid–liquid microextraction based on a double-solvent system (DLLME-DSS) was developed for the extraction and preconcentration of organophosphorus pesticides (OPPs) in the blood of children with acute leukaemia prior to determination by high-performance liquid chromatography-ultraviolet detection (HPLC-UV). In the present method, two long normal chain alcohols are mixed in a particular ratio, and then injected into the sample solution, which is magnetically stirred. In this case, the mixture of the two alcohols changes to a new aggregate extractant. This new double-solvent is used as an extractant, which has a higher extraction power than any of its components alone. Under the optimum conditions, the calibration graph was linear in the rage of 3–600 μg L−1 with detection limits of 1 to 2 μg L−1. Relative standard deviations (RSDs) including intra-day and inter-day of the method based on 7 replicate determinations of 100.0 μg L−1 for each analyte were in the range of 2.9–4.7% and 3.8–6.1%, respectively. The results proved that DLLME-DSS is a sensitive, very simple, inexpensive, environmentally friendly, rapid and efficient method for the preconcentration of trace amounts of OPPs in blood samples. |
| Databáze: | OpenAIRE |
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