Characteristics of finasteride users in comparison with nonusers: A Nordic nationwide study based on individual-level data from Denmark, Finland, and Sweden
| Autor: | Martha Emneus, Thora Majlund Kjærulff, Klaus Brasso, Eero Pukkala, Annette Kjær Ersbøll, Peter Iversen, Lau Caspar Thygesen, Anders Green, Kristian Bolin |
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| Přispěvatelé: | Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, Tampere University |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Data Analysis Male medicine.medical_specialty pharmacoepidemiology Epidemiology Kansanterveystiede ympäristö ja työterveys - Public health care science environmental and occupational health Denmark Population Logistic regression Testicular Diseases 030226 pharmacology & pharmacy Breast Neoplasms Male 03 medical and health sciences chemistry.chemical_compound 5-alpha Reductase Inhibitors 0302 clinical medicine Syöpätaudit - Cancers medicine Humans Pharmacology (medical) Registries 030212 general & internal medicine education Finland Aged Aged 80 and over Sweden education.field_of_study business.industry Finasteride registries Confounding Factors Epidemiologic Odds ratio Middle Aged Pharmacoepidemiology medicine.disease Confidence interval finasteride chemistry Case-Control Studies Male breast cancer surveys and questionnaires surveys and questionnaire business Demography Farmasia - Pharmacy |
| Zdroj: | Kjærulff, T M, Ersbøll, A K, Pukkala, E, Bolin, K, Green, A, Emneus, M, Brasso, K, Iversen, P & Thygesen, L C 2020, ' Characteristics of finasteride users in comparison with nonusers : A Nordic nationwide study based on individual-level data from Denmark, Finland, and Sweden ', Pharmacoepidemiology and Drug Safety, vol. 29, no. 4, pp. 453-460 . https://doi.org/10.1002/pds.4947 Kjaerulff, T M, Ersbøll, A K, Pukkala, E, Bolin, K, Green, A, Emneus, M, Brasso, K, Iversen, P & Thygesen, L C 2020, ' Characteristics of finasteride users in comparison with nonusers : A Nordic nationwide study based on individual-level data from Denmark, Finland, and Sweden ', Pharmacoepidemiology and Drug Safety, vol. 29, no. 4, pp. 453-460 . https://doi.org/10.1002/pds.4947 |
| Popis: | PURPOSE: Published epidemiological studies on the association between finasteride use and the risk of male breast cancer have been inconclusive due to methodological limitations including a few male breast cancer cases included. Determinants of male breast cancer have been studied, but it remains unexplored whether these are also related to finasteride use and thereby constitute potential confounders. This study aimed to assess whether there are differences between finasteride users and nonusers with regard to numerous potential confounders.METHODS: In total, 246 508 finasteride users (≥35 years) were identified in the prescription registries of Denmark (1995-2014), Finland (1997-2013), and Sweden (2005-2014). An equal number of nonusers were sampled. The directed acyclic graph (DAG) methodology was used to identify potential confounders for the association between finasteride and male breast cancer. A logistic regression model compared finasteride users and nonusers with regard to potential confounders that were measurable in registries and population surveys.RESULTS: Finasteride users had higher odds of testicular abnormalities (odds ratio [OR] 1.40; 95% confidence interval [CI] 1.36-1.44), obesity (1.31; 1.23-1.39), exogenous testosterone (1.61; 1.48-1.74), radiation exposure (1.22; 1.18-1.27), and diabetes (1.07; 1.04-1.10) and lower odds of occupational exposure in perfume industry or in high temperature environments (0.93; 0.87-0.99), living alone (0.89; 0.88-0.91), living in urban/suburban areas (0.97; 0.95-0.99), and physical inactivity (0.70; 0.50-0.99) compared to nonusers.CONCLUSIONS: Systematic differences between finasteride users and nonusers were found emphasizing the importance of confounder adjustment of associations between finasteride and male breast cancer. |
| Databáze: | OpenAIRE |
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