Lymphocyte transformation induced by autologous cells. VIII. Impaired autologous mixed lymphocyte reactivity in patients with acute infectious mononucleosis
| Autor: | W N Christenson, Marc E. Weksler, C E Moody, B A Casazza |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Herpesvirus 4 Human Isoantigens Autologous cell Adolescent Mononucleosis T-Lymphocytes Lymphocyte media_common.quotation_subject Immunology chemical and pharmacologic phenomena Lymphocyte Activation Vaccines Attenuated Autoantigens Virus Humans Immunology and Allergy Medicine Rubella Vaccine In patient Infectious Mononucleosis media_common B-Lymphocytes business.industry Convalescence hemic and immune systems Articles medicine.disease Mixed lymphocyte reaction medicine.anatomical_structure Lymphocyte transformation Female Lymphocyte Culture Test Mixed business |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.150.6.1448 |
| Popis: | The autologous mixed lymphocyte reaction (MLR) is severely impaired in patients with acute infectious mononucleosis. Reactivity returned during the course of convalescence. The allogeneic MLR was not impaired in these patients. B cells from patients with infectious mononucleosis do not stimulate autologous T-cell proliferation, and this observation appears to explain the cellular basis of the impaired autologous MLR in infection. Two explanations for the B-cell defect were considered: (a) the influence of serum factors on B-cell function and (b) the effect of Epstein-Barr virus infection. |
| Databáze: | OpenAIRE |
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