Re-evaluation of the reward comparison hypothesis for alcohol abuse
| Autor: | Yu-Chieh Chang, Anna Wan Yun Meng, Alan Bo-Han He, Andrew Chih Wei Huang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Alcohol abuse Pharmacology Models Psychological 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound Random Allocation 0302 clinical medicine Saccharin Reward Conditioning Psychological medicine High doses Animals Rats Wistar Psychological Tests Ethanol Dose-Response Relationship Drug musculoskeletal neural and ocular physiology Low dose Classical conditioning Central Nervous System Depressants medicine.disease Conditioned place preference Alcoholism Disease Models Animal 030104 developmental biology chemistry Space Perception Taste aversion Psychology Social psychology psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | Behavioural brain research. 332 |
| ISSN: | 1872-7549 |
| Popis: | This study examined whether various doses of ethanol induced reward or aversion and then evaluated Grigson’s reward comparison hypothesis (1997). Rats were given a 0.1% saccharin solution (conditioned stimulus 1 [CS1]) 15 min prior to administration of a 0, 0.05, 0.125, 0.20, 0.35, or 0.50 g/kg dose of ethanol (unconditioned stimulus [US]). The rats were then exposed to a paired compartment (CS2) for 30 min. The low dose of 0.05 g/kg ethanol did not induce conditioned suppression (i.e., conditioned taste aversion [CTA]) or conditioned place preference (CPP). The dose of 0.125 g/kg ethanol induced CPP but not CTA. High doses of ethanol, including 0.35 g/kg and 0.50 g/kg, produced CTA but not CPP. The middle dose of 0.20 g/kg ethanol simultaneously induced CTA and CPP. As a result, the reward comparison hypothesis cannot explain the present finding that the middle dose of ethanol induced CTA and CPP. Meanwhile, the high doses of ethanol induced motivationally aversive CTA but not rewarding CPP. The reward comparison hypothesis should be updated further. |
| Databáze: | OpenAIRE |
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