Assessment of Executive Functions after Treatment of Childhood Acute Lymphoid Leukemia: a Systematic Review
Autor: | Priscilla Brandi Gomes Godoy, Deborah Suchecki, Claudia Berlim de Mello, Natalia Maria Simionato |
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Rok vydání: | 2020 |
Předmět: |
Male
Coping (psychology) Adolescent MEDLINE PsycINFO Disease Neuropsychological Tests 050105 experimental psychology Executive Function 03 medical and health sciences 0302 clinical medicine Humans 0501 psychology and cognitive sciences Survivors Child Childhood Acute Lymphoblastic Leukemia 05 social sciences Neuropsychology Precursor Cell Lymphoblastic Leukemia-Lymphoma Executive functions Neuropsychology and Physiological Psychology Quality of Life Female Psychology Neurocognitive 030217 neurology & neurosurgery Clinical psychology |
Zdroj: | Neuropsychology Review. 30:386-406 |
ISSN: | 1573-6660 1040-7308 |
DOI: | 10.1007/s11065-020-09446-4 |
Popis: | Individuals treated for childhood acute lymphoblastic leukemia (ALL) have a high survival rate. This fact, however, may lead to neurocognitive impairments in survivors, as shown in some studies. The prefrontal cortex and executive functions seem to be particularly vulnerable due to the late maturation in the development process. Executive impairments have been associated with poorer quality of life in childhood cancer survivors. A systematic review was carried out with studies that assessed executive functions in childhood ALL survivors.\ Studies were collected from five electronic databases: MEDLINE (PubMed); PsycInfo; WebOfScience; LILACS and IBECS. Eighty-four studies were retrieved from the database search, of which 50 were read in full and 26 met the inclusion criteria. The studies were heterogeneous as to the instruments used to assess executive function, the skills assessed and the comparison methods. Despite some discrepancies, ALL survivors seem to exhibit poorer executive functioning than typical controls, but this result did not hold true when subjects were compared to normative mean. Changes in brain structure and dynamics resulting from the disease itself, the toxicity of the treatment and difficulties in coping with the stress during treatment may be related to executive impairments in ALL survivors. Discussion proposed standardized methods and measures for assessing executive functioning in children during and after ALL treatment. |
Databáze: | OpenAIRE |
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