Thrombolytic therapy of cerebral arterial occlusion with recombinant tissue plasminogen activator
| Autor: | Gudrun Boysen, Jens Bjerre Knudsen, Jens Boesen, Karsten Overgaard, Hans Redersen, Gunhild Waldemar |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Arterial Occlusive Diseases medicine.artery Internal medicine Occlusion medicine Humans Thrombolytic Agent Thrombolytic Therapy Stroke Aged Cerebral infarction business.industry General Medicine Middle Aged medicine.disease Thrombosis Recombinant Proteins Catheter Regimen Neurology Tissue Plasminogen Activator Middle cerebral artery Cardiology Female Cerebral Arterial Diseases Neurology (clinical) Tomography X-Ray Computed business |
| Zdroj: | Neurological Research. 12:78-80 |
| ISSN: | 1743-1328 0161-6412 |
| DOI: | 10.1080/01616412.1990.11739920 |
| Popis: | This report describes three patients, with acute cerebral arterial occlusion, treated with recombinant tissue plasminogen activator (rt-PA). In one patient with basilar artery occlusion thrombolytic treatment was initiated 12 h after onset of the symptoms. In two patients with angiographically verified occlusion of the middle cerebral artery, the treatment was initiated approximately 4.5 h after onset of the symptoms. Recombinant tissue plasminogen activator 80-120 mg, was infused intra-arterially over 90-100 min via a catheter the tip of which was close to the occlusion. This regimen resulted in recanalization in all the patients; however, in two patients it was verified by repeat CT scan only. In two patients the thrombolytic treatment was successful (the patients improved clinically); the third patient died of massive cerebral infarct-related oedema. In none of the patients did significant bleeding or other obvious side-effects occur. From this preliminary report it is concluded that angiographically proven thrombolytic recanalization in acute cerebrovascular occlusion is possible with rt-PA. In some patients, however, the treatment is initiated too late. Further investigation of the possible indication for thrombolytic therapy in stroke is needed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|