Stability of an oral midazolam solution for premedication in paediatric patients
| Autor: | Dolors Soy, Eduardo L. Mariño, Carles Codina, L. Parra, M. Roca, Pilar Modamio, López Mc, E. Chabas, L. Salvador, J. Ribas |
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| Předmět: |
Male
medicine.medical_specialty Sedation Chemistry Pharmaceutical Midazolam Pharmaceutical Science Administration Oral Pharmacy Toxicology Drug Stability Oral midazolam medicine Humans Pharmacology (medical) Child Paediatric patients Pharmacology Venous puncture Drug compounding Chromatography business.industry Ventilatory function General Medicine Hydrogen-Ion Concentration Surgery Solutions Spectrophotometry Anesthesia Child Preschool Calibration Premedication Female medicine.symptom business Preanesthetic Medication medicine.drug |
| Zdroj: | Scopus-Elsevier |
| Popis: | The objectives of this study were to assess the stability of a 1 mg/ml oral midazolam solution elaborated by our Hospital Pharmacy Service, and to confirm its clinical elfect in presurgical paediatric patients. The solution's stability was tested by determining its pH and its UV-visible absorption spectrum at room temperature for up to 60 days. A high performance liquid chromatography method was used to confirm it. There was no significant change in pH value of either the test or a control solution. No loss of midazolam could be detected during the test. The Anaesthesiology Service assessed the sedation quality (very good, good, bad) and the venous puncture response, 20 minutes afier the administration of 0.3 mg/kg of an oral midazolam solution. Twenty children were examined (age: 4–7 years). In addition, the hacmodynamic and ventilatory functions were evaluated. |
| Databáze: | OpenAIRE |
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