Development and initial validation of a composite disease activity score for systemic juvenile idiopathic arthritis
| Autor: | Angela Pistorio, Waleed A. Hassan, Giovanni Conti, Adele Civino, Raed Alzyoud, Jutamas Yamsuwan, Elena Aldera, Claudia Bracaglia, Laura Puzone, Priyankar Pal, Sumidha Mittal, Hala M. Lotfy, Raju Khubchandani, Angelo Ravelli, Enrico Felici, Gabriella Giancane, Maria Cristina Maggio, Ghada Farouk Elderiny, Tapas K Sabui, Giovanni Filocamo, Rolando Cimaz, Soamarat Vilaiyuk, M Pardeo, Sulaiman M. Al-Mayouf, Claudia Saad Magalhães, I.A. Chikova, Yomna Farag, Flavio Sztajnbok, Pallavi Pimpale Chavan, Romina Gallizzi, S.I. Nasef, Masaki Shimizu, T. Dvoryakovskaya, Mervat Eissa, Mohammed Hassan Abu-Zaid, Ekaterina Alexeeva, Butsabong Lerkvaleekul, Pragati Datta, Hriday De, Prabhas Prasun Giri, Nicolino Ruperto, Alessandro Consolaro, Ricardo Russo, Yasser El Miedany, Francesca Minoia, Mikhail Kostik, Jessica Tibaldi, Edoardo Marrani, Sujata Sawhney, MM Katsicas, Motasem O. Alsuweiti, Fernanda Cardoso das Neves Sztajnbok |
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| Přispěvatelé: | IRCCS Istituto Giannina Gaslini, Università degli Studi di Genova, Ain Shams University, Institute of Child Health, SRCC Children's Hospital, Mahidol University, R G Kar Medical College, IRCCS Ospedale Pediatrico Bambino Gesù, Sir Ganga Ram Hospital, Benha University, Alexandria University, Tanta University, Cairo University, Universidade do Estado do Rio de Janeiro (UERJ), Universidade Federal do Rio de Janeiro (UFRJ), Hospital de Pediatría Garrahan, University of Milan, University Hospital Meyer, National Medical Research Center of Children's Health, Sechenov First Moscow State Medical University, Queen Rania Children's Hospital, Saint-Petersburg State Pediatric Medical University, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Suez Canal University, King Faisal Specialist Hospital and Research Center, Università degli Studi di Palermo, Universidade Estadual Paulista (Unesp), Azienda Ospedaliera Universitaria Gaetano Martino Messina, Azienda Ospedaliera Universitaria Gaetano Martino, Kanazawa University, Ospedale Vito Fazzi, AON SS Antonio e Biagio e Cesare Arrigo Children's Hospital, Tibaldi J., Pistorio A., Aldera E., Puzone L., El Miedany Y., Pal P., Giri P.P., De H., Khubchandani R., Chavan P.P., Vilaiyuk S., Lerkvaleekul B., Yamsuwan J., Sabui T.K., Datta P., Pardeo M., Bracaglia C., Sawhney S., Mittal S., Hassan W.A., Elderiny G.F., Abu-Zaid M.H., Eissa M., Sztajnbok F., das Neves Sztajnbok F.C., Russo R., Katsicas M.M., Cimaz R., Marrani E., Alexeeva E., Dvoryakovskaya T.M., Alsuweiti M.O., Alzyoud R.M., Kostik M., Chikova I., Minoia F., Filocamo G., Farag Y., Lotfy H., Nasef S.I., Al-Mayouf S.M., Maggio M.C., Magalhaes C.S., Gallizzi R., Conti G., Shimizu M., Civino A., Felici E., Giancane G., Ruperto N., Consolaro A., Ravelli A. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Clinical assessment Composite disease activity score Disease activity Outcome measures Pediatric rheumatology Still's disease Systemic juvenile idiopathic arthritis medicine.medical_specialty Fever Arthritis Lymphadenopathy Disease Severity of Illness Index Outcome measure Juvenile Arthritis Disease Activity Score Rheumatology Cronbach's alpha Internal medicine Content validity Medicine Juvenile Humans Pharmacology (medical) Range of Motion Articular Child Pain Measurement Serositis Thrombocytosis business.industry Construct validity Reproducibility of Results Anemia Exanthema medicine.disease Arthralgia Arthritis Juvenile Child Preschool Splenomegaly Quality of Life Female Hyperferritinemia business Hepatomegaly |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2021-06-25T10:38:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-11-01 Healthway Objective. To develop a composite disease activity score for systemic JIA (sJIA) and to provide preliminary evidence of its validity. Methods. The systemic Juvenile Arthritis Disease Activity Score (sJADAS) was constructed by adding to the four items of the original JADAS a fifth item that aimed to quantify the activity of systemic features. Validation analyses were conducted on patients with definite or probable/possible sJIA enrolled at first visit or at the time of a flare, who had active systemic manifestations, which should include fever. Patients were reassessed 2 weeks to 3 months after baseline. Three versions were examined, including ESR, CRP or no acute-phase reactant. Results. A total of 163 patients were included at 30 centres in 10 countries. The sJADAS was found to be feasible and to possess face and content validity, good construct validity, satisfactory internal consistency (Cronbach's alpha 0.64-0.65), fair ability to discriminate between patients with different disease activity states and between those whose parents were satisfied or not satisfied with illness outcome (P < 0.0001 for both), and strong responsiveness to change over time (standardized response mean 2.04-2.58). Overall, these properties were found to be better than those of the original JADAS and of DAS for RA and of Puchot score for adult-onset Still's disease. Conclusion. The sJADAS showed good measurement properties and is therefore a valid instrument for the assessment of disease activity in children with sJIA. The performance of the new tool should be further examined in other patient cohorts that are evaluated prospectively. UOC Clinica Pediatrica e Reumatologia IRCCS Istituto Giannina Gaslini Dipartimento di Neuroscienze Riabilitazione Oftalmologia Genetica e Scienze Materno-Infantili (DiNOGMI) Università degli Studi di Genova Dipartimento di Epidemiologia e Biostatistica IRCCS Istituto Giannina Gaslini Faculty of Medicine Ain Shams University Pediatric Rheumatology Division Institute of Child Health Section of Pediatric Rheumatology SRCC Children's Hospital Rheumatology Division Pediatric Department Faculty of Medicine Ramathibodi Hospital Mahidol University Pediatric Rheumatology Clinic R G Kar Medical College Division of Rheumatology IRCCS Ospedale Pediatrico Bambino Gesù Division of Pediatric Rheumatology Institute of Child Health Sir Ganga Ram Hospital Faculty of Medicine Benha University Faculty of Medicine Alexandria University Faculty of Medicine Tanta University Faculty of Medicine Cairo University Pediatric Rheumatology Division Adolescent Health Care Unit Universidade do Estado do Rio de Janeiro Department of Internal Medicine Universidade Federal do Rio de Janeiro Servicio de Inmunología y Reumatología Hospital de Pediatría Garrahan Department of Clinical Sciences and Community Health University of Milan Division of Rheumatology University Hospital Meyer Rheumatology Division National Medical Research Center of Children's Health Sechenov First Moscow State Medical University Department of Immunology Rheumatology and Allergy Queen Rania Children's Hospital Saint-Petersburg State Pediatric Medical University UOC Pediatria a Media Intensità di Cure Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Rheumatology Department Faculty of Medicine Suez Canal University Department of Pediatrics King Faisal Specialist Hospital and Research Center Dipartimento Promise G. D'Alessandro Università degli Studi di Palermo Pediatric Department Hospital das Clínicas Botucatu Medicine University UNESP UOC Pediatria Servizio di Immuno-Reumatologia Pediatrica Azienda Ospedaliera Universitaria Gaetano Martino Messina UO Nefrologia e Reumatologia Pediatrica Azienda Ospedaliera Universitaria Gaetano Martino Department of Pediatrics School of Medicine Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Pediatric Unit Ospedale Vito Fazzi Pediatric Unit AON SS Antonio e Biagio e Cesare Arrigo Children's Hospital Pediatric Department Hospital das Clínicas Botucatu Medicine University UNESP |
| Databáze: | OpenAIRE |
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