Linear antimicrobial peptides with activity against herpes simplex virus 1 and Aichi virus
| Autor: | Paula Andreia Silva, Lidia M. P. Lima, Liana Costa Pereira Vilas Boas, Maianne Gonçalves de Jesus, Ludovico Migliolo, Gabriele dos Santos Mendes, Octavio L. Franco |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Drug Kobuvirus Cell Survival viruses media_common.quotation_subject Antimicrobial peptides Biophysics Herpesvirus 1 Human medicine.disease_cause Antiviral Agents Biochemistry Virus Microbiology Biomaterials 03 medical and health sciences Anti-Infective Agents Chlorocebus aethiops medicine Animals Humans Amino Acid Sequence Vero Cells media_common Dose-Response Relationship Drug biology Organic Chemistry General Medicine biology.organism_classification Virology 030104 developmental biology Herpes simplex virus Mechanism of action Vero cell medicine.symptom Peptides Aichi virus |
| Zdroj: | Peptide Science. 108:e22871 |
| ISSN: | 1097-0282 0006-3525 |
| Popis: | Viruses are the major cause of disease and mortality worldwide. Nowadays there are treatments based on antivirals or prophylaxis with vaccines. However, the rising number of reports of viral resistance to current antivirals and the emergence of new types of virus has concerned the scientific community. In this scenario, the search for alternative treatments has led scientists to the discovery of antimicrobial peptides (AMPs) derived from many different sources. Since some of them have shown antiviral activities, here we challenged 10 synthetic peptides from different animal and plant sources against, herpes simplex virus 1 (HSV-1), and Aichi virus. Among them, the highlight was Pa-MAP from the polar fish Pleuronectes americanus, which caused around 90% of inhibition of the HSV with a selectivity index of 5 and a virucidal mechanism of action. Moreover, LL-37 from human neutrophils showed 96% of inhibition against the Aichi virus, showing a selectivity index of 3.4. The other evaluated peptides did not show significant antiviral activity. In conclusion, the present study demonstrated that Pa-MAP seems to be a reliable candidate for a possible alternative drug to treat HSV-1 infections. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 108: 1-6, 2017. |
| Databáze: | OpenAIRE |
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