Comparison of the effects of new folkloric hemostatic agent on peripheral nerve function: an electrophysiologic study in rats
| Autor: | A. Alper Pampu, Figen Cizmeci Senel, Mehmet Yildirim, Tamer Tüzüner, İsmail Abidin, Ezher Hamza Dayisoylu, Özgül Baygin |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Time Factors Oxidized cellulose Neural Conduction Action Potentials Positive control Hemostatics Nerve conduction velocity Pathology and Forensic Medicine Rats Sprague-Dawley Random Allocation chemistry.chemical_compound Sural Nerve Peripheral nerve Reaction Time Electrophysiologic study medicine Animals Cellulose Oxidized Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Ketamine Hemostatic Agent Plants Medicinal Plant Extracts business.industry Peroneal Nerve Sciatic Nerve Rats Oxidized regenerated cellulose chemistry Anesthesia Cattle Surgery Collagen Medicine Traditional Tibial Nerve Oral Surgery business medicine.drug |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 115:e1-e6 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2011.10.025 |
| Popis: | Objective The aim was to evaluate the effects of a new folkloric medicinal plant extract on peripheral nerve function compared with oxidized regenerated cellulose (OC) and bovine collagen (BC). Study Design Under ketamine anesthesia a total of 40 male Sprague-Dawley rat right sciatic nerves were identified. Animals were randomly divided into 5 groups: OC, BC, ankaferd blood stopper (ABS), and negative and positive control groups. The recordings of nerve potentials were carried out using an electrophysiologic data acquisition system. After the application of substances, the nerve conduction velocity (NCV) was recorded for immediate (30 min), early (120 min), and delayed (3 wk) effects on nerve function. Results Statistically, differences were not found among the hemostatic agents (OC, BC, and ABS) at baseline and all tested periods (early, immediate, and delayed; P > .05). The positive control group exhibited lower NCV values compared with the other solutions at the 30-minute period ( P P > .05). OC exhibited NCV values closer to the positive control group at 120 minutes ( P > .05). Conclusions Folkloric medicinal hemostatic agent could be considered as an acceptable hemostatic material without resulting in any serious peripheral nerve function alterations. The possible desirable effects of bovine collagen and undesirable effects of oxidized cellulose on peripheral nerve function should not be overlooked. |
| Databáze: | OpenAIRE |
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