Regulatory T Cells and Parasites
| Autor: | Olusola Ojurongbe, Thirumalaisamy P. Velavan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Regulatory T cell
Health Toxicology and Mutagenesis lcsh:Biotechnology Population lcsh:Medicine Antigen-Presenting Cells Review Article Biology T-Lymphocytes Regulatory Host-Parasite Interactions Immune system lcsh:TP248.13-248.65 Genetics medicine Parasitic Diseases Animals Humans Parasites Antigen-presenting cell education Molecular Biology Regulator gene Immunosuppression Therapy education.field_of_study Polymorphism Genetic Effector Host (biology) Mechanism (biology) lcsh:R General Medicine medicine.anatomical_structure Immunology Molecular Medicine Biotechnology |
| Zdroj: | Journal of Biomedicine and Biotechnology Journal of Biomedicine and Biotechnology, Vol 2011 (2011) |
| ISSN: | 1110-7251 1110-7243 |
| Popis: | Human host encounters a wide array of parasites; however, the crucial aspect is the failure of the host immune system to clear these parasites despite antigen recognition. In the recent past, a new immunological concept has emerged, which provides a framework to better understand several aspects of host susceptibility to parasitic infection. It is widely believed that parasites are able to modulate the magnitude of effector responses by inducing regulatory T cell (Tregs) population and several studies have investigated whether this cell population plays a role in balancing protective immunity and pathogenesis during parasite infection. This review discusses the several mechanism of Treg-mediated immunosuppression in the human host and focuses on the functional role of Tregs and regulatory gene polymorphisms in infectious diseases. |
| Databáze: | OpenAIRE |
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