Sequential restoration of external limiting membrane and ellipsoid zone after intravitreal anti-VEGF therapy in diabetic macular oedema
| Autor: | Malvika Singh, Sandeep Saxena, Apjit Kaur, Arvind Misra, Levent Akduman, Abbas Ali Mahdi, Carsten H. Meyer, Somnath De |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures Macular Edema Retina Article Post-intervention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology Humans Medicine Intravitreal bevacizumab External limiting membrane Retrospective Studies Anti vegf Diabetic Retinopathy business.industry Retinal Bevacizumab Clinical trial medicine.anatomical_structure Diabetes Mellitus Type 2 Diabetic macular oedema chemistry 030221 ophthalmology & optometry medicine.symptom business Tomography Optical Coherence 030217 neurology & neurosurgery |
| Zdroj: | Eye (Lond) |
| ISSN: | 1476-5454 0950-222X |
| Popis: | BACKGROUND/OBJECTIVES: To study the mechanism of restoration of retinal photoreceptor ellipsoid zone (EZ), after intravitreal bevacizumab (IVB) therapy, in diabetic macular oedema (DMO). SUBJECTS/METHODS: Forty-four consecutive patients aged 40–65 years having type 2 diabetes mellitus (DM) with DMO were prospectively recruited for IVB therapy. It comprised of three doses (1.25 mg in 0.05 ml) of IVB at monthly intervals. Patients with other ocular and systemic diseases affecting retinal vessels and earlier ophthalmological interventions were excluded. Visual acuity (logMAR VA) was recorded. Spectral domain optical coherence tomography (SD-OCT) was performed pre and post intervention. Central sub-foveal thickness (CST) and grades of disorganization of retinal inner layers (DRIL), external limiting membrane (ELM) and EZ were assessed. Data were statistically analysed on SPSS software. Clinical trials registry: CTRI/2019/03/018135. RESULTS: Mean logMAR VA decreased after IVB therapy from 1.78 ± 0.07 pre-intervention to 0.42 ± 0.05 post intervention (p |
| Databáze: | OpenAIRE |
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