Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase

Autor:	Ann Greer, Stoffan Karen M, Joan M. Carboni, Bruce L. Jacobson, Zoeckler Mary Edson, Marco M. Gottardis, Dolatrai M. Vyas, Ricardo M. Attar, Aixin Li, Steven Hansel, Subramaniam Krishnanathan, Mark D. Wittman, Pieying Liu, Chiehying Chang, Yax Sun, Upender Velaparthi, Balu Balasubramanian
Rok vydání:	2007
Předmět:	Models Molecular Pyridones medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Biochemistry Cell Line Mice Structure-Activity Relationship Insulin-like growth factor Growth factor receptor Drug Discovery medicine Animals Structure–activity relationship Insulin-Like Growth Factor I Molecular Biology Cell Proliferation chemistry.chemical_classification biology Kinase Growth factor Phosphotransferases Organic Chemistry Enzyme chemistry Enzyme inhibitor biology.protein Molecular Medicine Benzimidazoles Indicators and Reagents Signal transduction Baculoviridae Thymidine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 17:974-977
ISSN:	0960-894X
Popis:	A novel class of 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase is described. This report discusses the SAR of 4-(2-hydroxy-2-phenylethylamino)-substituted pyridones with improved IGF-1R potency.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c951ab3913e0e3f58e4cf105cfa4a1d4 https://doi.org/10.1016/j.bmcl.2006.11.041 Zobrazit plný text záznamu Full Text from ScienceDirect