Synergic activity of vancomycin-quinupristin/dalfopristin combination against Enterococcus faecium
| Autor: | Victor Lorian, F Fernandes |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Microbiology (medical)
medicine.medical_treatment Enterococcus faecium Colony Count Microbial Dalfopristin Microbial Sensitivity Tests Biology Virginiamycin Microbiology chemistry.chemical_compound Vancomycin polycyclic compounds medicine Humans Pharmacology (medical) Antibacterial agent Pharmacology Teicoplanin Quinupristin Drug Synergism biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Streptococcaceae Quinupristin/dalfopristin Infectious Diseases chemistry Drug Therapy Combination medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 39:63-66 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/39.suppl_1.63 |
| Popis: | Clinical specimens were cultured, and the strains identified by the Vitek system as Enterococcus faecium were characterized by their DNA. The MIC vancomycin, quinupristin/ dalfopristin and teicoplanin for each isolate was determined. Ten vancomycin-sensitive and ten vancomycin-resistant strains of E. faecium were tested. Quinupristin/dalfopristin at 0.25 x MIC and vancomycin at 0.5 x MIC separately as well as in combination were added to Trypticase Soy Broth tubes inoculated with a 24 h culture. The results obtained by determining cfu at 2, 4, 8, 12 and 24 h indicated that the combination of subinhibitory concentrations of quinupristin/dalfopristin plus vancomycin produced after 24 h, in vancomycin-resistant strains, a consistent degree of synergy. Synergy was observed up to only 12 h when similar combinations were employed for vancomycin-sensitive strains. Vancomycin-sensitive strains tended to be slightly less susceptible to quinupristin/ dalfopristin than vancomycin-resistant strains. |
| Databáze: | OpenAIRE |
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