Impaired context processing as a potential marker of psychosis risk state
Autor: | J. Daniel Ragland, Jong H. Yoon, Cameron S. Carter, Andrew J. Westphal, Marjorie Solomon, Natalie Hutchison, Michael J. Minzenberg, Tyler A. Lesh, Tara A. Niendam |
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Rok vydání: | 2014 |
Předmět: |
Male
Neuropsychological Tests Audiology Medical and Health Sciences Cognition Risk Factors 2.1 Biological and endogenous factors Aetiology Young adult Prefrontal cortex Pediatric Psychiatry medicine.diagnostic_test fMRI Middle Aged Clinical high risk Serious Mental Illness Magnetic Resonance Imaging Psychiatry and Mental health Mental Health medicine.anatomical_structure Schizophrenia Ultra high risk Biomedical Imaging Female Psychology Psychosocial Adult Psychosis medicine.medical_specialty Neuroscience (miscellaneous) Prefrontal Cortex behavioral disciplines and activities Article Young Adult Clinical Research Behavioral and Social Science medicine Humans Radiology Nuclear Medicine and imaging Prevention Psychology and Cognitive Sciences Neurosciences medicine.disease Brain Disorders Dorsolateral prefrontal cortex Psychotic Disorders Socioeconomic Factors Case-Control Studies Cognition Disorders Functional magnetic resonance imaging Psychomotor Performance |
Zdroj: | Psychiatry research, vol 221, iss 1 |
ISSN: | 0925-4927 |
Popis: | While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. |
Databáze: | OpenAIRE |
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