Impaired context processing as a potential marker of psychosis risk state

Autor: J. Daniel Ragland, Jong H. Yoon, Cameron S. Carter, Andrew J. Westphal, Marjorie Solomon, Natalie Hutchison, Michael J. Minzenberg, Tyler A. Lesh, Tara A. Niendam
Rok vydání: 2014
Předmět:
Male
Neuropsychological Tests
Audiology
Medical and Health Sciences
Cognition
Risk Factors
2.1 Biological and endogenous factors
Aetiology
Young adult
Prefrontal cortex
Pediatric
Psychiatry
medicine.diagnostic_test
fMRI
Middle Aged
Clinical high risk
Serious Mental Illness
Magnetic Resonance Imaging
Psychiatry and Mental health
Mental Health
medicine.anatomical_structure
Schizophrenia
Ultra high risk
Biomedical Imaging
Female
Psychology
Psychosocial
Adult
Psychosis
medicine.medical_specialty
Neuroscience (miscellaneous)
Prefrontal Cortex
behavioral disciplines and activities
Article
Young Adult
Clinical Research
Behavioral and Social Science
medicine
Humans
Radiology
Nuclear Medicine and imaging
Prevention
Psychology and Cognitive Sciences
Neurosciences
medicine.disease
Brain Disorders
Dorsolateral prefrontal cortex
Psychotic Disorders
Socioeconomic Factors
Case-Control Studies
Cognition Disorders
Functional magnetic resonance imaging
Psychomotor Performance
Zdroj: Psychiatry research, vol 221, iss 1
ISSN: 0925-4927
Popis: While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis.
Databáze: OpenAIRE
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