Small, dense low-density lipoproteins (LDL) are predictors of cardio- and cerebro-vascular events in subjects with the metabolic syndrome
| Autor: | Vincenzo Pernice, Gabriele Di Lorenzo, A. Frasheri, Manfredi Rizzo, Kaspar Berneis, Giovam Battista Rini, Giatgen A. Spinas |
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| Přispěvatelé: | University of Zurich, Rizzo, M, Pernice, V, Frasheri, A, Di Lorenzo, G, Rini, GB, Spinas, GA, Berneis, K |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism 10265 Clinic for Endocrinology and Diabetology 610 Medicine & health Cerebro Coronary artery disease Endocrinology Predictive Value of Tests Risk Factors Internal medicine medicine Humans Family history Low-density lipoproteins (LDL metabolic syndrome Aged Metabolic Syndrome Univariate analysis business.industry Middle Aged medicine.disease 1310 Endocrinology Lipoproteins LDL 2712 Endocrinology Diabetes and Metabolism medicine.anatomical_structure Small dense low-density lipoproteins cardio events cerebro-vascular events the metabolic syndrome Cardiovascular Diseases Predictive value of tests Circulatory system Female Metabolic syndrome business Blood vessel Follow-Up Studies |
| Popis: | Summary Objective Small, dense low-density lipoproteins (LDL) are a feature of the metabolic syndrome (MS) but their predictive role still remains to be established. We performed a 2-year follow-up study in 124 subjects with MS (63 ± 6 years), as defined by the American Heart Association/National Heart, Lung and Blood Institute guidelines, to assess clinical and biochemical predictors of cerebro- and cardio-vascular events. Methods and results Beyond traditional cardiovascular risk factors, we measured LDL size and subclasses by gradient gel electrophoresis. Clinical events were registered in the 25% of subjects. At univariate analysis subjects with events had increased prevalence of elevated fasting glucose (P = 0·0117), smoking (P = 0·0015), family history of coronary artery disease (P = 0·0033) and higher levels of total- and LDL-cholesterol (P = 0·0027 and P = 0·0023, respectively); LDL size was lower (P |
| Databáze: | OpenAIRE |
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