Oral microbiota reveals signs of acculturation in Mexican American women

Autor: K. Hoffman, Paul Scheet, Diane S. Hutchinson, Carrie R. Daniel, Jerry Fowler, Nadim J. Ajami, Wong Ho Chow, Daniel P. Smith, Joseph F. Petrosino, Hua Zhao
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Mexican People
Prevotella
lcsh:Medicine
Pathology and Laboratory Medicine
Geographical locations
0302 clinical medicine
Oral Diseases
Mexican Americans
Medicine and Health Sciences
Ethnicities
Young adult
lcsh:Science
Multidisciplinary
biology
Microbiota
Genomics
Fusobacterium
Middle Aged
Population groupings
Acculturation
Bacterial Pathogens
3. Good health
Medical Microbiology
Female
Oral Microbiome
Pathogens
Research Article
Cohort study
Adult
Oral Medicine
Emigrants and Immigrants
Microbial Genomics
Microbiology
Fusobacteria
Young Adult
03 medical and health sciences
Genetics
medicine
Humans
Microbiome
Microbial Pathogens
Mexico
Aged
Periodontitis
Mouth
Bacteria
business.industry
Gut Bacteria
lcsh:R
Organisms
Streptococcus
Biology and Life Sciences
Latin American people
030206 dentistry
biology.organism_classification
medicine.disease
Obesity
United States
stomatognathic diseases
030104 developmental biology
North America
lcsh:Q
People and places
business
Demography
Zdroj: PLoS ONE, Vol 13, Iss 4, p e0194100 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: The oral microbiome has been linked to a number of chronic inflammatory conditions, including obesity, diabetes, periodontitis, and cancers of the stomach and liver. These conditions disproportionately affect Mexican American women, yet few studies have examined the oral microbiota in this at-risk group. We characterized the 16S rDNA oral microbiome in 369 non-smoking women enrolled in the MD Anderson Mano a Mano Mexican American Cohort Study. Lower bacterial diversity, a potential indicator of oral health, was associated with increased age and length of US residency among recent immigrants. Grouping women by overarching bacterial community type (e.g., “Streptococcus,” “Fusobacterium,” and “Prevotella” clusters), we observed differences across a number of acculturation-related variables, including nativity, age at immigration, time in the US, country of longest residence, and a multi-dimensional acculturation scale. Participants in the cluster typified by higher abundance of Streptococcus spp. exhibited the lowest bacterial diversity and appeared the most acculturated as compared to women in the “Prevotella” group. Computationally-predicted functional analysis suggested the Streptococcus-dominated bacterial community had greater potential for carbohydrate metabolism while biosynthesis of essential amino acids and nitrogen metabolism prevailed among the Prevotella-high group. Findings suggest immigration and adaption to life in the US, a well-established mediator of disease risk, is associated with differences in oral microbial profiles in Mexican American women. These results warrant further investigation into the joint and modifying effects of acculturation and oral bacteria on the health of Mexican American women and other immigrant populations. The oral microbiome presents an easily accessible biomarker of disease risk, spanning biological, behavioral, and environmental factors.
Databáze: OpenAIRE
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