Proteasome Inhibition With Bortezomib (PS-341): A Phase I Study With Pharmacodynamic End Points Using a Day 1 and Day 4 Schedule in a 14-Day Cycle
| Autor: | Anna C. Pavlick, P. Elliott, Leonard Liebes, Rocio Garcia-Carbonero, Franco M. Muggia, Anne Hamilton, Abraham Chachoua, V. Soma, J. Boyden, Anne Zeleniuch-Jacquotte, David P. Ryan, K. Farrell, Jeffrey W. Clark, John Wright, Judith Adams, Nancy M. Kinchla, Herman Yee, Joseph Paul Eder |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Proteasome Endopeptidase Complex Cancer Research medicine.medical_specialty Proteasome Inhibition Lymphoma Antineoplastic Agents Pharmacology Drug Administration Schedule Bortezomib Neoplasms Peripheral Nervous System Humans Medicine Infusions Intravenous Aged business.industry Middle Aged medicine.disease Boronic Acids Surgery Phase i study Treatment Outcome Peripheral neuropathy Oncology Pyrazines Total dose Pharmacodynamics Toxicity Female business Proteasome Inhibitors medicine.drug |
| Zdroj: | Journal of Clinical Oncology. 23:6107-6116 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2005.01.136 |
| Popis: | Purpose We performed a phase I study of a day (D) 1 and D4 bortezomib administration once every 2 weeks to determine the recommended phase II dose and toxicity profile, and the extent of 20S proteasome inhibition obtained. Patients and Methods Patients with solid tumors or lymphomas were treated with bortezomib at 0.25 to 1.9 mg/m2 on D1 and D4, every 2 weeks. 20S proteasome levels in blood were assayed at baseline and at 1, 4, and 24 hours postdose in cycle 1. Results On this D1 and D4 every 2 weeks' schedule, dose-limiting toxicity (DLT) was evident at the 1.75 and 1.9 mg/m2 dose levels, most commonly in patients receiving individual total doses ≥ 3.0 mg. The main DLT was peripheral neuropathy evident at the higher doses and in patients previously exposed to neurotoxic agents. Other DLTs included diarrhea and fatigue; grade 3 thrombocytopenia was also noted. Reversible inhibition of 20S proteasome activity was dose dependent and best fit a total dose (mg) per fraction rather than mg/m2; 70% of baseline activity was inhibited by a dose of 3.0 to 3.5 mg given on D1 and on D4 every other week. Antitumor effects short of confirmed partial responses were observed in patients with melanoma, non–small-cell lung cancer, and renal cell carcinoma. Conclusion Bortezomib (PS-341) is a novel antineoplastic agent that is well tolerated at doses not exceeding 3.0 mg (equivalent to 1.75 mg/m2), repeated on D1 and D4 every other week. This dose correlates with 70% inhibition of 20S proteasome activity. DLTs include neuropathy, fatigue, and diarrhea. |
| Databáze: | OpenAIRE |
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