| Popis: |
The aim of this paper is to discuss structural identifiability of two recently proposed bio-chemical models: the first quantitatively describes a specific pathway, in two cell lines derived from two clinically different hematologic tumors, opening the possibility to guide the identification of therapeutic targets. The second model investigates the receptor properties that critically determine processing of ligand-encoded information. The model provides important results on the information processing at the erythropoietin (EPO) receptor. For both these models, the differential-algebra based approach provides a direct check of global identifiability, showing the non-identifiability of some model parameters. The approach suggests a reduction of the model to minimal form so that fundamental system theoretic properties, such as accessibility, hold and the model is more suitable to further mathematical investigations. |
