Levamisole plus 5-fluorouracil inhibits the growth of human colorectal xenografts in nude mice
| Autor: | W. Distelmans, Robert Van Ginckel, Myriam Callens, Boudewijn Janssens, Marc De Brabander, Luc Wouters, Roland De Coster, Els Jagers, Paul A. J. Janssen |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Ratón medicine.medical_treatment Transplantation Heterologous Mice Nude Pharmacology Adenocarcinoma Mice Renal capsule Antineoplastic Combined Chemotherapy Protocols Adjuvant therapy medicine Animals Humans Chemotherapy business.industry Rectal Neoplasms Cancer Levamisole medicine.disease Transplantation medicine.anatomical_structure Oncology Fluorouracil Colonic Neoplasms business Neoplasm Transplantation medicine.drug |
| Zdroj: | European journal of cancer (Oxford, England : 1990). (6-7) |
| ISSN: | 0959-8049 |
| Popis: | Fragments of human colorectal adenocarcinomas were inserted under the renal capsule of nude mice. The growth of these tumour grafts was significantly inhibited by the combination of 5-fluorouracil (5-FU) and levamisole. An alternating regimen of levamisole 2.5 mg/kg and 5-FU 20 mg/kg decreased the size of tumour implants by 33-59% and/or increased the number of macroscopically disappeared fragments in the combined group compared with ineffective monotherapy with saline, levamisole or 5-FU. This model could be valuable for investigating the mechanism of action of levamisole and to evaluate the effects of this adjuvant therapy in other oncological settings. |
| Databáze: | OpenAIRE |
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