Postmenopausal craniofacial hyperhidrosis treated with botulinum toxin type B
Autor: | Philip Cabreus, Alma Rystedt, Carl Swartling |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Injections Intradermal Dermatology Placebo law.invention Placebos 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Quality of life Randomized controlled trial law Internal medicine medicine Humans Hyperhidrosis Medical history Botulinum Toxins Type A Aged Aged 80 and over Vasomotor business.industry General Medicine Dermatology Life Quality Index Middle Aged Botulinum toxin Postmenopause Treatment Outcome 030220 oncology & carcinogenesis Face Quality of Life Female medicine.symptom business Head medicine.drug |
Zdroj: | The Journal of dermatologyReferences. 46(10) |
ISSN: | 1346-8138 |
Popis: | Hyperhidrosis can seriously impair patients' quality of life. Medical history, including heredity and hyperhidrosis during youth, as well as current age and time elapsed since menopause, is important to consider when distinguishing between postmenopausal hyperhidrosis and vasomotor symptoms to enable adequate treatment. This report concerns a subgroup of eight postmenopausal patients participating in a randomized controlled trial regarding botulinum toxin (Btx) type B treatment in craniofacial hyperhidrosis. Even though the sample size is small and the enrolment is not yet completed, the promising data collected hitherto are interesting to present in advance because this subtype of craniofacial hyperhidrosis is often underrecognized and challenging to treat. Patients were randomized to receive Btx type B or placebo. Measurements were performed before treatment and 3 ± 1 weeks after. The Dermatology Life Quality Index (DLQI) score was improved for all patients after Btx type B treatment (n = 3) with a median decrease of 9 points (90% median improvement). The placebo group (n = 5) had a median increase of 2 points (-18% median decline). When the same group (n = 5) received Btx type B (open) the DLQI score decreased with a median of 7 points compared with baseline (91% median improvement). Treatment-related adverse events were temporary and did not prevent improvement of life quality. Furthermore, background data evaluation uncovered interesting findings regarding vasomotor symptoms in relation to postmenopausal hyperhidrosis. In conclusion, the results indicated that Btx type B seems to be a safe and effective treatment in postmenopausal craniofacial hyperhidrosis. Further research is encouraged. |
Databáze: | OpenAIRE |
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