Evaluation of the children with acute acetaminophen overdose and intravenous N-acetylcysteine treatment
| Autor: | Yakup Yeşil, Abdurrahman Avar Özdemir |
|---|---|
| Přispěvatelé: | Biruni Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
acetaminophen overdose
medicine.medical_treatment Acetylcysteine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Ingestion 030212 general & internal medicine Antidote Prospective cohort study Children Creatinine business.industry digestive oral and skin physiology 030208 emergency & critical care medicine General Medicine N- Acetylcysteine Acetaminophen chemistry Anesthesia Original Article Acetaminophen Intoxication business Complication medicine.drug |
| Zdroj: | Pakistan Journal of Medical Sciences |
| Popis: | Objective: To evaluate the demographic and clinical features associated with acetaminophen overdose and to identify the clinical use of IV (intravenous) N- Acetylcysteine (NAC) treatment in children. Methods: This prospective study was conducted in Kanuni Sultan Suleyman Training and Research Hospital between August 2016 and August 2017. A total of 59 patients with overdose acetaminophen ingestion were included in this study. The toxic dose for acute acetaminophen intake was defined as greater than 150 mg/kg. Rumack-Matthew nomogram was used to evaluate the risk of acute intoxication and to determine the decision of using antidote. Results: The mean age of the patients was 8.5 +/- 6.4 y and 34 of them (58%) were female. The mean time from ingestion to admission was 4.3 +/- 4.7 h. The mean ingested acetaminophen dose was 142.1 +/- 80 mg/kg. Twenty four patients (41%) received NAC and there were significant differences in terms of acetaminophen dose, creatinine and INR between antidote and decontamination therapy groups at admission time (p= 0.00, p= 0.03, p= 0.02, respectively). The complication due to antidote therapy was observed in only 1 patient. Conclusions: This study confirms that the side effects due to IV NAC therapy are uncommon and it is generally well tolerated in children. |
| Databáze: | OpenAIRE |
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