Chitosan in Surface Modification for Bone Tissue Engineering Applications
| Autor: | Badrinath Ashwin, Balakrishnan Abinaya, Syamala Viji Chandran, Nagarajan Selvamurugan, Tandiakkal Prakash Prasith |
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| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Bone Regeneration Materials science Surface Properties Biocompatible Materials Bone tissue 01 natural sciences Applied Microbiology and Biotechnology Bone and Bones Bone tissue engineering Chitosan chemistry.chemical_compound Osteogenesis 010608 biotechnology medicine Animals Humans Autografts Bone regeneration Tissue Engineering Regeneration (biology) 010401 analytical chemistry Biomaterial Prostheses and Implants General Medicine Plastic Surgery Procedures Allografts 0104 chemical sciences medicine.anatomical_structure chemistry Molecular Medicine Surface modification Disease transmission Biomedical engineering |
| Zdroj: | Biotechnology Journal. 14:1900171 |
| ISSN: | 1860-7314 1860-6768 |
| DOI: | 10.1002/biot.201900171 |
| Popis: | Traditional methods of bone defect repair include autografts, allografts, surgical reconstruction, and metal implants that have several disadvantages such as donor site morbidity, rejection, risk of disease transmission, and repetitive surgery. Biomaterial-based bone reconstructions can, therefore, be an efficient alternative due to the inherent properties of the materials. Chitosan (CS), the deacetylated form of chitin, is a biopolymer having a wide array of applicability in regenerative tissue applications owing to its biocompatible, in vitro degradative and bioresorbable nature. Extensive studies are being carried out using CS to augment the properties of the already existing methods and to also improve the applicability of CS-based biocomposites in bone tissue repair. In this review, the suitability of CS as a surface modifier has been discussed in detail for the already existing implants, surface modifications of CS-based natural biocomposites for bone tissue regeneration, and the wide range of techniques that can introduce these modifications. CS, being a natural polymer, possesses advantageous properties including surface modifier that makes it a suitable candidate for bone regeneration, and further research to investigate its osteogenic potential in vivo along with the molecular and signaling mechanisms involved in bone regeneration can aid in expanding its applicability in clinical trials. |
| Databáze: | OpenAIRE |
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