Enantioselective Synthesis of Spirorhodanine-Pyran Derivatives via Organocatalytic [3 + 3] Annulation Reactions between Pyrazolones and Rhodanine-Derived Ketoesters

Autor:	Yong-Chun Luo, Dong-Sheng Ji, Xiu-Qin Hu, Peng-Fei Xu
Rok vydání:	2020
Předmět:	Annulation 010405 organic chemistry Organic Chemistry Enantioselective synthesis 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Rhodanine chemistry Pyran Pyrazolones Physical and Theoretical Chemistry
Zdroj:	Organic letters. 22(3)
ISSN:	1523-7052
Popis:	A series of novel biselectrophilic β,γ-unsaturated α-ketoesters were designed and synthesized from rhodanine. Under the catalysis of chiral squaramides, the enantioselective [3 + 3] annulation reaction of these novel ketoesters with pyrazolones was developed. This reaction offers an efficient method for the synthesis of chiral 2'-thioxo-5,6-dihydrospiro[pyrano[2,3
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c943561d1fbf08acdf70a9283d4e0c25 https://pubmed.ncbi.nlm.nih.gov/31939306 Zobrazit plný text záznamu