Fibrogenesis in Granulomas and Lung Interstitium in Tuberculous Inflammation in Mice
| Autor: | L. B. Kim, L. A. Cherdantseva, A. N. Putyatina, O. V. Potapova, I. K. Nikonova, V. A. Shkurupiy |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Pulmonary Fibrosis Inflammation General Biochemistry Genetics and Molecular Biology Granulomatous inflammation Mice Hydroxyproline chemistry.chemical_compound Pulmonary fibrosis medicine Animals Lung Tuberculosis Pulmonary Pathogen Cell Proliferation Mice Inbred BALB C Granuloma Tumor Necrosis Factor-alpha business.industry Macrophages General Medicine Mononuclear phagocyte system Fibroblasts medicine.disease Mycobacterium bovis Disease Models Animal medicine.anatomical_structure chemistry Immunology BCG Vaccine medicine.symptom business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 156:731-735 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-014-2435-y |
| Popis: | The study in mouse model of BCG-induced granulomatous inflammation showed that early pulmonary fibrosis (day 3-30 postinfection) in tuberculous inflammation was primarily determined by increased number of fibroblasts in the lung interstitium and granulomas and enhanced fibroplastic activity. Fibroplastic processes are initiated via an increase in secretory activity of activated granuloma macrophages caused by the persistence of the pathogen in the cells of the mononuclear phagocytic system. The dynamics of hydroxyproline concentration under these conditions is determined by changes in the number and differentiation degree of fibroblasts in granulomas and lung interstitium at various stages of tuberculous inflammation. |
| Databáze: | OpenAIRE |
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